Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspartate--tRNA ligase (Escherichia coli) | BDBM50339907 (((S)-2-amino-3-carboxypropanoyl)(((2R,3S,4R,5R)-5-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.0520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Inhibition of Escherichia coli BL21(DE3) Aspartyl-tRNA synthetase assessed as reduction in tRNA aminoacylation preincubated for 10 mins with Escheric... | Eur J Med Chem 148: 384-396 (2018) Article DOI: 10.1016/j.ejmech.2018.02.013 BindingDB Entry DOI: 10.7270/Q2057JJS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aspartate--tRNA ligase (Escherichia coli) | BDBM18127 (3-amino-4-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 15 | -46.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
CREFSIP | Assay Description The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p... | Bioorg Med Chem 13: 69-75 (2005) Article DOI: 10.1016/j.bmc.2004.09.055 BindingDB Entry DOI: 10.7270/Q2S75DM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aspartate--tRNA ligase (Escherichia coli) | BDBM50458117 (CHEMBL4203761) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Inhibition of Escherichia coli BL21(DE3) Aspartyl-tRNA synthetase assessed as reduction in tRNA aminoacylation preincubated for 10 mins with Escheric... | Eur J Med Chem 148: 384-396 (2018) Article DOI: 10.1016/j.ejmech.2018.02.013 BindingDB Entry DOI: 10.7270/Q2057JJS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aspartate--tRNA ligase (Escherichia coli) | BDBM18126 (3-amino-5-({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 123 | -41.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
CREFSIP | Assay Description The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p... | Bioorg Med Chem 13: 69-75 (2005) Article DOI: 10.1016/j.bmc.2004.09.055 BindingDB Entry DOI: 10.7270/Q2S75DM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aspartate--tRNA ligase (Escherichia coli) | BDBM18124 ((3S)-3-amino-4-[({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.50E+4 | -25.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
CREFSIP | Assay Description The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p... | Bioorg Med Chem 13: 69-75 (2005) Article DOI: 10.1016/j.bmc.2004.09.055 BindingDB Entry DOI: 10.7270/Q2S75DM3 | |||||||||||
More data for this Ligand-Target Pair |