Found 21 hits of ic50 for UniProtKB: P09626 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000672
(6-Methoxy-4-methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quin...)Show InChI InChI=1S/C20H18N2O/c1-13-7-4-5-9-17(13)22-12-11-15-14(2)21-19-16(20(15)22)8-6-10-18(19)23-3/h4-12H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000668
(2-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)Show InChI InChI=1S/C21H21N3O/c1-14-6-3-4-9-18(14)24-12-10-17-20(24)16-8-5-7-15(2)19(16)23-21(17)22-11-13-25/h3-10,12,25H,11,13H2,1-2H3,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000675
(CHEMBL54511 | Methyl-(6-methyl-1-o-tolyl-2,3-dihyd...)Show InChI InChI=1S/C20H21N3/c1-13-7-4-5-10-17(13)23-12-11-16-19(23)15-9-6-8-14(2)18(15)22-20(16)21-3/h4-10H,11-12H2,1-3H3,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000673
(6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)Show InChI InChI=1S/C19H19N3/c1-12-6-3-4-9-16(12)22-11-10-15-18(22)14-8-5-7-13(2)17(14)21-19(15)20/h3-9H,10-11H2,1-2H3,(H2,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000677
(4-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)Show InChI InChI=1S/C23H25N3O/c1-16-8-3-4-11-20(16)26-14-12-19-22(26)18-10-7-9-17(2)21(18)25-23(19)24-13-5-6-15-27/h3-4,7-12,14,27H,5-6,13,15H2,1-2H3,(H,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000684
((6-Methoxy-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]...)Show InChI InChI=1S/C20H21N3O/c1-13-7-4-5-9-16(13)23-12-11-15-19(23)14-8-6-10-17(24-3)18(14)22-20(15)21-2/h4-10H,11-12H2,1-3H3,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000666
(2-(6-Methoxy-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-...)Show InChI InChI=1S/C21H23N3O2/c1-14-6-3-4-8-17(14)24-12-10-16-20(24)15-7-5-9-18(26-2)19(15)23-21(16)22-11-13-25/h3-9,25H,10-13H2,1-2H3,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000682
(CHEMBL292179 | [1-(4-Methoxy-2-methyl-phenyl)-6-me...)Show InChI InChI=1S/C21H23N3O/c1-13-6-5-7-16-19(13)23-21(22-3)17-10-11-24(20(16)17)18-9-8-15(25-4)12-14(18)2/h5-9,12H,10-11H2,1-4H3,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000680
(CHEMBL52811 | Methyl-(6-methyl-1-o-tolyl-1H-pyrrol...)Show InChI InChI=1S/C20H19N3/c1-13-7-4-5-10-17(13)23-12-11-16-19(23)15-9-6-8-14(2)18(15)22-20(16)21-3/h4-12H,1-3H3,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000667
(3-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)Show InChI InChI=1S/C22H23N3O/c1-15-7-3-4-10-19(15)25-13-11-18-21(25)17-9-5-8-16(2)20(17)24-22(18)23-12-6-14-26/h3-5,7-11,13,26H,6,12,14H2,1-2H3,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000679
(6-Methoxy-1-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrr...)Show InChI InChI=1S/C19H19N3O2/c1-23-15-8-4-3-7-14(15)22-11-10-13-18(22)12-6-5-9-16(24-2)17(12)21-19(13)20/h3-9H,10-11H2,1-2H3,(H2,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000670
(8-Methoxy-4-o-tolylamino-quinoline-2-carboxylic ac...)Show InChI InChI=1S/C20H20N2O3/c1-4-25-20(23)17-12-16(21-15-10-6-5-8-13(15)2)14-9-7-11-18(24-3)19(14)22-17/h5-12H,4H2,1-3H3,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000685
(6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)Show InChI InChI=1S/C19H18N2/c1-13-6-3-4-9-17(13)21-11-10-15-12-20-18-14(2)7-5-8-16(18)19(15)21/h3-9,12H,10-11H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000681
(CHEMBL54813 | Dimethyl-(6-methyl-1-o-tolyl-2,3-dih...)Show InChI InChI=1S/C21H23N3/c1-14-8-5-6-11-18(14)24-13-12-17-20(24)16-10-7-9-15(2)19(16)22-21(17)23(3)4/h5-11H,12-13H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000686
((8-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[2,3-b]q...)Show InChI InChI=1S/C25H23N3/c1-17-9-6-7-14-22(17)28-16-15-21-24(26-19-11-4-3-5-12-19)20-13-8-10-18(2)23(20)27-25(21)28/h3-14H,15-16H2,1-2H3,(H,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000671
((1-o-Tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-4...)Show InChI InChI=1S/C19H18N2O/c1-13-6-2-5-9-18(13)21-11-10-15-17(12-22)20-16-8-4-3-7-14(16)19(15)21/h2-9,22H,10-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000669
(6-Methoxy-1-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrr...)Show InChI InChI=1S/C19H18N2O2/c1-22-16-8-4-3-7-15(16)21-11-10-13-12-20-18-14(19(13)21)6-5-9-17(18)23-2/h3-9,12H,10-11H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000676
(1-Methyl-3-(6-methyl-1-o-tolyl-2,3-dihydro-1H-pyrr...)Show InChI InChI=1S/C21H22N4O/c1-13-7-4-5-10-17(13)25-12-11-16-19(25)15-9-6-8-14(2)18(15)23-20(16)24-21(26)22-3/h4-10H,11-12H2,1-3H3,(H2,22,23,24,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000678
((6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]q...)Show InChI InChI=1S/C20H20N4O/c1-12-6-3-4-9-16(12)24-11-10-15-18(24)14-8-5-7-13(2)17(14)22-19(15)23-20(21)25/h3-9H,10-11H2,1-2H3,(H3,21,22,23,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000674
(4-Chloro-6-methoxy-1-(2-methoxy-phenyl)-2,3-dihydr...)Show InChI InChI=1S/C19H17ClN2O2/c1-23-15-8-4-3-7-14(15)22-11-10-13-18(22)12-6-5-9-16(24-2)17(12)21-19(13)20/h3-9H,10-11H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description The compound was evaluated for the inhibition of gastric H+/K+ ATPase |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |
Potassium-transporting ATPase alpha chain 1/subunit beta
(Rattus norvegicus) | BDBM50000683
(6-Methoxy-1-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrr...)Show InChI InChI=1S/C19H18N2O3/c1-23-15-8-4-3-7-14(15)21-11-10-13-18(21)12-6-5-9-16(24-2)17(12)20-19(13)22/h3-9H,10-11H2,1-2H3,(H,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R&D
Curated by ChEMBL
| Assay Description Inhibition of rat isolated gastric(H+/K+)-ATPase. |
J Med Chem 35: 1845-52 (1992)
BindingDB Entry DOI: 10.7270/Q2SQ8ZB3 |
More data for this Ligand-Target Pair | |