Found 37 hits of ic50 for UniProtKB: O60894 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541411
(CHEMBL4643006)Show SMILES CC(C)c1ccc(nn1)-c1ccc(Oc2cc(ccc2CN2C[C@@H](C)CC2=O)C(=O)N[C@@H]2CCN(C[C@@H]2F)C2CCOCC2)cc1 |r| Show InChI InChI=1S/C36H44FN5O4/c1-23(2)31-10-11-32(40-39-31)25-6-8-29(9-7-25)46-34-19-26(4-5-27(34)21-42-20-24(3)18-35(42)43)36(44)38-33-12-15-41(22-30(33)37)28-13-16-45-17-14-28/h4-11,19,23-24,28,30,33H,12-18,20-22H2,1-3H3,(H,38,44)/t24-,30-,33+/m0/s1 | PDB
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| n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 by cAMP assay |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184069
(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)Show SMILES NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCN(CC1)c1ccncc1 Show InChI InChI=1S/C38H47Br2N9O5/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53)/t32-,33+/m0/s1 | PDB
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| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541409
(CHEMBL4647045)Show SMILES COC(C)(C)c1cc(ccn1)-c1cc(ncc1N(C)c1cc(C)nc(C)c1)N1CCC(CC1)N1Cc2ccccc2NC(=O)C1 Show InChI InChI=1S/C36H43N7O2/c1-24-17-29(18-25(2)39-24)41(5)32-21-38-34(20-30(32)26-11-14-37-33(19-26)36(3,4)45-6)42-15-12-28(13-16-42)43-22-27-9-7-8-10-31(27)40-35(44)23-43/h7-11,14,17-21,28H,12-13,15-16,22-23H2,1-6H3,(H,40,44) | PDB
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Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 by cAMP assay |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184069
(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)Show SMILES NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCN(CC1)c1ccncc1 Show InChI InChI=1S/C38H47Br2N9O5/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53)/t32-,33+/m0/s1 | PDB
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Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541412
(CHEMBL4644508)Show SMILES CN1CCN(CC1)C1CCN(CC1)C(=O)[C@H](CC(=O)N1CCC(CC1)N1CCc2ccccc2NC1=O)Cc1cc(Cl)c(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C36H47ClF3N7O3/c1-43-16-18-44(19-17-43)27-7-13-46(14-8-27)34(49)26(20-24-21-29(36(38,39)40)33(41)30(37)22-24)23-32(48)45-11-9-28(10-12-45)47-15-6-25-4-2-3-5-31(25)42-35(47)50/h2-5,21-22,26-28H,6-20,23,41H2,1H3,(H,42,50)/t26-/m0/s1 | PDB
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Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541404
(CHEMBL4639133)Show SMILES NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCN(CC1)c1ccncc1 |r| Show InChI InChI=1S/C37H45Br2N9O5/c38-27-21-24(22-28(39)33(27)49)23-31(44-36(52)47-15-10-26(11-16-47)48-32-7-2-1-5-29(32)43-37(48)53)34(50)42-30(6-3-4-12-40)35(51)46-19-17-45(18-20-46)25-8-13-41-14-9-25/h1-2,5,7-9,13-14,21-22,26,30-31,49H,3-4,6,10-12,15-20,23,40H2,(H,42,50)(H,43,53)(H,44,52)/t30-,31+/m0/s1 | PDB
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Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50047356
(CHEMBL3334624)Show SMILES Cc1cc(C[C@@H](OC(=O)N2CCC(CC2)N2CCc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCOCC2)cc(C)c1O |r| Show InChI InChI=1S/C35H47N5O6/c1-24-21-26(22-25(2)32(24)41)23-31(33(42)38-12-8-28(9-13-38)37-17-19-45-20-18-37)46-35(44)39-14-10-29(11-15-39)40-16-7-27-5-3-4-6-30(27)36-34(40)43/h3-6,21-22,28-29,31,41H,7-20,23H2,1-2H3,(H,36,43)/t31-/m1/s1 | PDB
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| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217493
(CHEMBL235237 | N-((3R,6S)-1-(cyclopropylmethyl)-2-...)Show SMILES O=C(N[C@@H]1CC[C@H](CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)n1cc([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C31H37N5O3/c37-29-27(14-13-25(23-7-3-1-4-8-23)20-35(29)19-22-11-12-22)32-30(38)34-17-15-26(16-18-34)36-21-28(33-31(36)39)24-9-5-2-6-10-24/h1-10,21-22,25-27H,11-20H2,(H,32,38)(H,33,39)/t25-,27-/m1/s1 | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541403
(CHEMBL4641806)Show SMILES NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)N(C(N)=O)c1ccccc1)C(=O)N1CCN(CC1)c1ccncc1 |r| Show InChI InChI=1S/C37H47Br2N9O5/c38-29-22-25(23-30(39)33(29)49)24-32(44-37(53)47-16-11-28(12-17-47)48(36(41)52)27-6-2-1-3-7-27)34(50)43-31(8-4-5-13-40)35(51)46-20-18-45(19-21-46)26-9-14-42-15-10-26/h1-3,6-7,9-10,14-15,22-23,28,31-32,49H,4-5,8,11-13,16-21,24,40H2,(H2,41,52)(H,43,50)(H,44,53)/t31-,32+/m0/s1 | PDB
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| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217485
(CHEMBL394229 | N-((3R,6S)-1-(cyclopropylmethyl)-2-...)Show SMILES O=C(N[C@@H]1CC[C@H](CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1CCc2ccccc2NC1=O Show InChI InChI=1S/C31H39N5O3/c37-29-28(13-12-25(23-6-2-1-3-7-23)21-35(29)20-22-10-11-22)33-30(38)34-17-15-26(16-18-34)36-19-14-24-8-4-5-9-27(24)32-31(36)39/h1-9,22,25-26,28H,10-21H2,(H,32,39)(H,33,38)/t25-,28-/m1/s1 | PDB
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217495
(CHEMBL429262 | N-((3R,6S)-1-(cyclopropylmethyl)-2-...)Show SMILES O=C(N[C@@H]1CC[C@H](CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1Cc2ccccc2NC1=O Show InChI InChI=1S/C30H37N5O3/c36-28-27(13-12-23(22-6-2-1-3-7-22)19-34(28)18-21-10-11-21)32-29(37)33-16-14-25(15-17-33)35-20-24-8-4-5-9-26(24)31-30(35)38/h1-9,21,23,25,27H,10-20H2,(H,31,38)(H,32,37)/t23-,27-/m1/s1 | PDB
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184071
((R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-...)Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:13| Show InChI InChI=1S/C31H29F3N6O3/c32-31(33,34)19-40-25-13-7-5-11-23(25)26(20-8-2-1-3-9-20)36-27(28(40)41)37-29(42)38-16-14-22(15-17-38)39-18-21-10-4-6-12-24(21)35-30(39)43/h1-13,22,27H,14-19H2,(H,35,43)(H,37,42)/t27-/m0/s1 | PDB
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Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184072
((R)-4-(2-oxo-1,2,4,5-tetrahydrobenzo[d][1,3]diazep...)Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2CCc3ccccc3NC2=O)C1=O)c1ccccc1 |c:13| Show InChI InChI=1S/C32H31F3N6O3/c33-32(34,35)20-41-26-13-7-5-11-24(26)27(22-9-2-1-3-10-22)37-28(29(41)42)38-30(43)39-17-15-23(16-18-39)40-19-14-21-8-4-6-12-25(21)36-31(40)44/h1-13,23,28H,14-20H2,(H,36,44)(H,38,43)/t28-/m0/s1 | PDB
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Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50047357
(CHEMBL3334623)Show SMILES NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)n1c2ccccc2oc1=O)C(=O)N1CCN(CC1)c1ccncc1 |r| Show InChI InChI=1S/C37H44Br2N8O6/c38-27-21-24(22-28(39)33(27)48)23-30(43-36(51)46-15-10-26(11-16-46)47-31-6-1-2-7-32(31)53-37(47)52)34(49)42-29(5-3-4-12-40)35(50)45-19-17-44(18-20-45)25-8-13-41-14-9-25/h1-2,6-9,13-14,21-22,26,29-30,48H,3-5,10-12,15-20,23,40H2,(H,42,49)(H,43,51)/t29-,30+/m0/s1 | PDB
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| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217488
(CHEMBL392132 | N-((3R,6S)-1-(cyclopropylmethyl)-2-...)Show SMILES O=C(N[C@@H]1CC[C@H](CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)n1nc([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H36N6O3/c37-28-26(14-13-24(22-7-3-1-4-8-22)20-35(28)19-21-11-12-21)31-29(38)34-17-15-25(16-18-34)36-30(39)32-27(33-36)23-9-5-2-6-10-23/h1-10,21,24-26H,11-20H2,(H,31,38)(H,32,33,39)/t24-,26-/m1/s1 | PDB
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| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217486
((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)Show SMILES O=C(NC1CCC(CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1Cc2ccccc2NC1=O Show InChI InChI=1S/C30H37N5O3/c36-28-27(13-12-23(22-6-2-1-3-7-22)19-34(28)18-21-10-11-21)32-29(37)33-16-14-25(15-17-33)35-20-24-8-4-5-9-26(24)31-30(35)38/h1-9,21,23,25,27H,10-20H2,(H,31,38)(H,32,37) | PDB
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| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217486
((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)Show SMILES O=C(NC1CCC(CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1Cc2ccccc2NC1=O Show InChI InChI=1S/C30H37N5O3/c36-28-27(13-12-23(22-6-2-1-3-7-22)19-34(28)18-21-10-11-21)32-29(37)33-16-14-25(15-17-33)35-20-24-8-4-5-9-26(24)31-30(35)38/h1-9,21,23,25,27H,10-20H2,(H,31,38)(H,32,37) | PDB
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| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217498
((R,Z)-N-(1-isopropyl-2-oxo-5-phenyl-2,3-dihydro-1H...)Show SMILES CC(C)N1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:11| Show InChI InChI=1S/C32H34N6O3/c1-21(2)38-27-15-9-7-13-25(27)28(22-10-4-3-5-11-22)34-29(30(38)39)35-31(40)36-18-16-24(17-19-36)37-20-23-12-6-8-14-26(23)33-32(37)41/h3-15,21,24,29H,16-20H2,1-2H3,(H,33,41)(H,35,40)/t29-/m0/s1 | PDB
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184074
((R)-N-(3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-(4-...)Show SMILES Oc1c(Br)cc(C[C@@H](NC(=O)N2CCC(CC2)n2c3ccccc3[nH]c2=O)C(=O)N2CCN(CC2)c2ccccc2)cc1Br Show InChI InChI=1S/C32H34Br2N6O4/c33-24-18-21(19-25(34)29(24)41)20-27(30(42)38-16-14-37(15-17-38)22-6-2-1-3-7-22)36-31(43)39-12-10-23(11-13-39)40-28-9-5-4-8-26(28)35-32(40)44/h1-9,18-19,23,27,41H,10-17,20H2,(H,35,44)(H,36,43)/t27-/m1/s1 | PDB
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| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217483
((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-phe...)Show SMILES O=C(NC1CC(CCN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)n1cc([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C31H37N5O3/c37-29-27(19-25(23-7-3-1-4-8-23)13-16-35(29)20-22-11-12-22)32-30(38)34-17-14-26(15-18-34)36-21-28(33-31(36)39)24-9-5-2-6-10-24/h1-10,21-22,25-27H,11-20H2,(H,32,38)(H,33,39) | PDB
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| n/a | n/a | 133 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217483
((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-phe...)Show SMILES O=C(NC1CC(CCN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)n1cc([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C31H37N5O3/c37-29-27(19-25(23-7-3-1-4-8-23)13-16-35(29)20-22-11-12-22)32-30(38)34-17-14-26(15-18-34)36-21-28(33-31(36)39)24-9-5-2-6-10-24/h1-10,21-22,25-27H,11-20H2,(H,32,38)(H,33,39) | PDB
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| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541402
(CHEMBL4645875)Show SMILES COc1ccccc1C1CCN(CC1)C(=O)N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN(CC1)c1ccncc1 |r| Show InChI InChI=1S/C37H47Br2N7O5/c1-51-33-8-3-2-6-28(33)26-11-16-46(17-12-26)37(50)43-32(24-25-22-29(38)34(47)30(39)23-25)35(48)42-31(7-4-5-13-40)36(49)45-20-18-44(19-21-45)27-9-14-41-15-10-27/h2-3,6,8-10,14-15,22-23,26,31-32,47H,4-5,7,11-13,16-21,24,40H2,1H3,(H,42,48)(H,43,50)/t31-,32+/m0/s1 | PDB
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| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217490
(CHEMBL428547 | N-((3R,7R)-1-(cyclopropylmethyl)-2-...)Show SMILES O=C(N[C@@H]1CCC[C@@H](N(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1Cc2ccccc2NC1=O Show InChI InChI=1S/C30H37N5O3/c36-28-26(11-6-12-27(22-7-2-1-3-8-22)35(28)19-21-13-14-21)32-29(37)33-17-15-24(16-18-33)34-20-23-9-4-5-10-25(23)31-30(34)38/h1-5,7-10,21,24,26-27H,6,11-20H2,(H,31,38)(H,32,37)/t26-,27-/m1/s1 | PDB
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| n/a | n/a | 408 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217482
(CHEMBL236516 | tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2...)Show SMILES CC(C)(C)OC(=O)CN1[C@@H](CCC[C@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 Show InChI InChI=1S/C32H41N5O5/c1-32(2,3)42-28(38)21-37-27(22-10-5-4-6-11-22)15-9-14-26(29(37)39)34-30(40)35-18-16-24(17-19-35)36-20-23-12-7-8-13-25(23)33-31(36)41/h4-8,10-13,24,26-27H,9,14-21H2,1-3H3,(H,33,41)(H,34,40)/t26-,27-/m0/s1 | PDB
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| n/a | n/a | 471 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217491
((cis racemic)-N-((3R)-1-(cyclopropylmethyl)-2-oxo-...)Show SMILES O=C(NC1CC(CCN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)n1nc([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H36N6O3/c37-28-26(19-24(22-7-3-1-4-8-22)13-16-35(28)20-21-11-12-21)31-29(38)34-17-14-25(15-18-34)36-30(39)32-27(33-36)23-9-5-2-6-10-23/h1-10,21,24-26H,11-20H2,(H,31,38)(H,32,33,39) | PDB
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| n/a | n/a | 488 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217491
((cis racemic)-N-((3R)-1-(cyclopropylmethyl)-2-oxo-...)Show SMILES O=C(NC1CC(CCN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)n1nc([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H36N6O3/c37-28-26(19-24(22-7-3-1-4-8-22)13-16-35(28)20-21-11-12-21)31-29(38)34-17-14-25(15-18-34)36-30(39)32-27(33-36)23-9-5-2-6-10-23/h1-10,21,24-26H,11-20H2,(H,31,38)(H,32,33,39) | PDB
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| n/a | n/a | 488 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184068
((R)-N-(1-ethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo...)Show SMILES CCN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:10| Show InChI InChI=1S/C31H32N6O3/c1-2-36-26-15-9-7-13-24(26)27(21-10-4-3-5-11-21)33-28(29(36)38)34-30(39)35-18-16-23(17-19-35)37-20-22-12-6-8-14-25(22)32-31(37)40/h3-15,23,28H,2,16-20H2,1H3,(H,32,40)(H,34,39)/t28-/m0/s1 | PDB
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| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50541401
(CHEMBL4634626)Show SMILES COc1ccccc1CCNC(=O)N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN(CC1)c1ccncc1 |r| Show InChI InChI=1S/C34H43Br2N7O5/c1-48-30-8-3-2-6-24(30)9-15-39-34(47)41-29(22-23-20-26(35)31(44)27(36)21-23)32(45)40-28(7-4-5-12-37)33(46)43-18-16-42(17-19-43)25-10-13-38-14-11-25/h2-3,6,8,10-11,13-14,20-21,28-29,44H,4-5,7,9,12,15-19,22,37H2,1H3,(H,40,45)(H2,39,41,47)/t28-,29+/m0/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184075
((R)-4-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)-N-(...)Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)n2c3ccccc3[nH]c2=O)C1=O)c1ccccc1 |r,c:13| Show InChI InChI=1S/C30H27F3N6O3/c31-30(32,33)18-38-23-12-6-4-10-21(23)25(19-8-2-1-3-9-19)35-26(27(38)40)36-28(41)37-16-14-20(15-17-37)39-24-13-7-5-11-22(24)34-29(39)42/h1-13,20,26H,14-18H2,(H,34,42)(H,36,41)/t26-/m0/s1 | PDB
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| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184076
((R,S)-N-(1-isopropyl-2-oxo-5-phenyl-2,3-dihydro-1H...)Show SMILES CC(C)N1c2ccccc2C(=NC(NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:11| Show InChI InChI=1S/C32H34N6O3/c1-21(2)38-27-15-9-7-13-25(27)28(22-10-4-3-5-11-22)34-29(30(38)39)35-31(40)36-18-16-24(17-19-36)37-20-23-12-6-8-14-26(23)33-32(37)41/h3-15,21,24,29H,16-20H2,1-2H3,(H,33,41)(H,35,40) | PDB
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| n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217482
(CHEMBL236516 | tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2...)Show SMILES CC(C)(C)OC(=O)CN1[C@@H](CCC[C@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 Show InChI InChI=1S/C32H41N5O5/c1-32(2,3)42-28(38)21-37-27(22-10-5-4-6-11-22)15-9-14-26(29(37)39)34-30(40)35-18-16-24(17-19-35)36-20-23-12-7-8-13-25(23)33-31(36)41/h4-8,10-13,24,26-27H,9,14-21H2,1-3H3,(H,33,41)(H,34,40)/t26-,27-/m0/s1 | PDB
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| n/a | n/a | 2.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217489
((R)-N-(1-(cyclopropylmethyl)-2-oxoazepan-3-yl)-4-(...)Show SMILES O=C(N[C@@H]1CCCCN(CC2CC2)C1=O)N1CCC(CC1)N1Cc2ccccc2NC1=O Show InChI InChI=1S/C24H33N5O3/c30-22-21(7-3-4-12-28(22)15-17-8-9-17)26-23(31)27-13-10-19(11-14-27)29-16-18-5-1-2-6-20(18)25-24(29)32/h1-2,5-6,17,19,21H,3-4,7-16H2,(H,25,32)(H,26,31)/t21-/m1/s1 | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217492
(CHEMBL238203 | N-(1-isopropyl-2-oxo-2,3,4,5-tetrah...)Show SMILES CC(C)N1c2ccccc2CCC(NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O Show InChI InChI=1S/C27H33N5O3/c1-18(2)32-24-10-6-4-7-19(24)11-12-23(25(32)33)29-26(34)30-15-13-21(14-16-30)31-17-20-8-3-5-9-22(20)28-27(31)35/h3-10,18,21,23H,11-17H2,1-2H3,(H,28,35)(H,29,34) | PDB
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| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184070
((R)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:9| Show InChI InChI=1S/C30H30N6O3/c1-34-25-14-8-6-12-23(25)26(20-9-3-2-4-10-20)32-27(28(34)37)33-29(38)35-17-15-22(16-18-35)36-19-21-11-5-7-13-24(21)31-30(36)39/h2-14,22,27H,15-19H2,1H3,(H,31,39)(H,33,38)/t27-/m0/s1 | PDB
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| n/a | n/a | 3.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50184067
((S)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:9| Show InChI InChI=1S/C30H30N6O3/c1-34-25-14-8-6-12-23(25)26(20-9-3-2-4-10-20)32-27(28(34)37)33-29(38)35-17-15-22(16-18-35)36-19-21-11-5-7-13-24(21)31-30(36)39/h2-14,22,27H,15-19H2,1H3,(H,31,39)(H,33,38)/t27-/m1/s1 | PDB
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| n/a | n/a | 4.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry Merck & Co.
Curated by ChEMBL
| Assay Description
Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP production |
Bioorg Med Chem Lett 16: 2595-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.051
BindingDB Entry DOI: 10.7270/Q2HT2NX8 |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50217496
(CHEMBL235015 | N-((3S,6R)-1-(cyclopropylmethyl)-2-...)Show SMILES O=C(N[C@H]1CC[C@@H](CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1Cc2ccccc2NC1=O Show InChI InChI=1S/C30H37N5O3/c36-28-27(13-12-23(22-6-2-1-3-7-22)19-34(28)18-21-10-11-21)32-29(37)33-16-14-25(15-17-33)35-20-24-8-4-5-9-26(24)31-30(35)38/h1-9,21,23,25,27H,10-20H2,(H,31,38)(H,32,37)/t23-,27-/m0/s1 | PDB
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PubMed
| n/a | n/a | 6.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production |
Bioorg Med Chem Lett 17: 4795-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.062
BindingDB Entry DOI: 10.7270/Q2JS9Q4D |
More data for this
Ligand-Target Pair | |
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human)) | BDBM50173483
((S)-6-Amino-2-[(R)-3-(3,5-dibromo-4-hydroxy-phenyl...)Show SMILES NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 Show InChI InChI=1S/C33H40Br2N4O4/c34-26-20-25(21-27(35)31(26)41)22-29(38-30(40)16-9-14-23-10-3-1-4-11-23)33(43)39-28(15-7-8-18-36)32(42)37-19-17-24-12-5-2-6-13-24/h1-6,10-13,20-21,28-29,41H,7-9,14-19,22,36H2,(H,37,42)(H,38,40)(H,39,43)/t28-,29+/m0/s1 | PDB
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| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Biohaven Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human CLR/RAMP1 |
J Med Chem 63: 6600-6623 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01810
BindingDB Entry DOI: 10.7270/Q2GF0Z1G |
More data for this
Ligand-Target Pair | |
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