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Compile Data Set for Download or QSAR

Found 444 hits of ki data for complexid = 50003576   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207303
PNG
(US9260439, 487)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@]1(C)CCN(C1)C(=O)C(C)(N)CO
Show InChI InChI=1/C24H35N9O3/c1-15-12-36-9-8-32(15)22-29-18(16-10-27-21(25)28-11-16)17-4-6-33(19(17)30-22)23(2)5-7-31(13-23)20(35)24(3,26)14-34/h10-11,15,34H,4-9,12-14,26H2,1-3H3,(H2,25,27,28)/t15-,23-,24?/s2
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0.0110n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207169
PNG
(US9260439, 146)
Show SMILES CC1(CCN(C1)S(C)(=O)=O)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C20H28N8O3S/c1-20(4-6-27(13-20)32(2,29)30)28-5-3-15-16(14-11-22-18(21)23-12-14)24-19(25-17(15)28)26-7-9-31-10-8-26/h11-12H,3-10,13H2,1-2H3,(H2,21,22,23)
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0.0150n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207387
PNG
(US9260439, 271)
Show SMILES CC(C)[C@@H](O)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H34N8O3/c1-15(2)19(33)21(34)31-7-5-24(3,14-31)32-6-4-17-18(16-12-26-22(25)27-13-16)28-23(29-20(17)32)30-8-10-35-11-9-30/h12-13,15,19,33H,4-11,14H2,1-3H3,(H2,25,26,27)/t19-,24+/m1/s1
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0.0160n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207312
PNG
(US9260439, 496)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@]1(C)CCN(C1)C(=O)C1(F)CCN1
Show InChI InChI=1/C24H32FN9O2/c1-15-13-36-10-9-33(15)22-30-18(16-11-27-21(26)28-12-16)17-3-7-34(19(17)31-22)23(2)5-8-32(14-23)20(35)24(25)4-6-29-24/h11-12,15,29H,3-10,13-14H2,1-2H3,(H2,26,27,28)/t15-,23-,24?/s2
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207324
PNG
(US9260439, 508)
Show SMILES COC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1/C22H30N8O3/c1-14-12-33-9-8-29(14)20-26-17(15-10-24-19(23)25-11-15)16-4-6-30(18(16)27-20)22(2)5-7-28(13-22)21(31)32-3/h10-11,14H,4-9,12-13H2,1-3H3,(H2,23,24,25)/t14-,22-/s2
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PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207326
PNG
(US9260439, 510)
Show SMILES C[C@@H]1CN(C[C@@]1(C)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C)C(=O)OC(C)(C)C
Show InChI InChI=1/C26H38N8O3/c1-16-13-32(24(35)37-25(3,4)5)15-26(16,6)34-8-7-19-20(18-11-28-22(27)29-12-18)30-23(31-21(19)34)33-9-10-36-14-17(33)2/h11-12,16-17H,7-10,13-15H2,1-6H3,(H2,27,28,29)/t16-,17+,26-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207328
PNG
(US9260439, 512)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@]1(C)CCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1/C25H36N8O3/c1-16-14-35-11-10-32(16)22-29-19(17-12-27-21(26)28-13-17)18-6-8-33(20(18)30-22)25(5)7-9-31(15-25)23(34)36-24(2,3)4/h12-13,16H,6-11,14-15H2,1-5H3,(H2,26,27,28)/t16-,25-/s2
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207343
PNG
(US9260439, 527)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@]12C[C@@H]1CN(C2)C(=O)OC(C)(C)C
Show InChI InChI=1/C25H34N8O3/c1-15-13-35-8-7-32(15)22-29-19(16-10-27-21(26)28-11-16)18-5-6-33(20(18)30-22)25-9-17(25)12-31(14-25)23(34)36-24(2,3)4/h10-11,15,17H,5-9,12-14H2,1-4H3,(H2,26,27,28)/t15-,17+,25+/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207033
PNG
(US9260439, 9)
Show SMILES CC1(C)COC(=N1)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C24H33N9O2/c1-23(2)15-35-22(30-23)32-7-5-24(3,14-32)33-6-4-17-18(16-12-26-20(25)27-13-16)28-21(29-19(17)33)31-8-10-34-11-9-31/h12-13H,4-11,14-15H2,1-3H3,(H2,25,26,27)/t24-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207028
PNG
(US9260439, 10 | US9260439, 4)
Show SMILES CC(C)(N)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C23H33N9O2/c1-22(2,25)19(33)31-7-5-23(3,14-31)32-6-4-16-17(15-12-26-20(24)27-13-15)28-21(29-18(16)32)30-8-10-34-11-9-30/h12-13H,4-11,14,25H2,1-3H3,(H2,24,26,27)/t23-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207185
PNG
(US9260439, 162)
Show SMILES CNS(=O)(=O)N1CCC(C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C20H29N9O3S/c1-20(4-6-28(13-20)33(30,31)22-2)29-5-3-15-16(14-11-23-18(21)24-12-14)25-19(26-17(15)29)27-7-9-32-10-8-27/h11-12,22H,3-10,13H2,1-2H3,(H2,21,23,24)
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207196
PNG
(US9260439, 173)
Show SMILES CNS(=O)(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C20H29N9O3S/c1-20(4-6-28(13-20)33(30,31)22-2)29-5-3-15-16(14-11-23-18(21)24-12-14)25-19(26-17(15)29)27-7-9-32-10-8-27/h11-12,22H,3-10,13H2,1-2H3,(H2,21,23,24)/t20-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207217
PNG
(US9260439, 194 | US9260439, 238 | US9260439, 239)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C24H34N8O3/c1-23(2,3)35-22(33)31-8-6-24(4,15-31)32-7-5-17-18(16-13-26-20(25)27-14-16)28-21(29-19(17)32)30-9-11-34-12-10-30/h13-14H,5-12,15H2,1-4H3,(H2,25,26,27)/t24-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207227
PNG
(US9260439, 204)
Show SMILES CC(C)S(=O)(=O)N1CC(C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1/C22H32N8O3S/c1-14(2)34(31,32)28-12-22(4,13-28)30-6-5-17-18(16-9-24-20(23)25-10-16)26-21(27-19(17)30)29-7-8-33-11-15(29)3/h9-10,14-15H,5-8,11-13H2,1-4H3,(H2,23,24,25)/t15-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207349
PNG
(US9260439, 233)
Show SMILES CC(C)(N)C(=O)N1CC[C@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C23H33N9O2/c1-22(2,25)19(33)31-7-5-23(3,14-31)32-6-4-16-17(15-12-26-20(24)27-13-15)28-21(29-18(16)32)30-8-10-34-11-9-30/h12-13H,4-11,14,25H2,1-3H3,(H2,24,26,27)/t23-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207352
PNG
(US9260439, 236 | US9260439, 237)
Show SMILES CC1(CC1)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C24H32N8O2/c1-23(4-5-23)20(33)31-8-6-24(2,15-31)32-7-3-17-18(16-13-26-21(25)27-14-16)28-22(29-19(17)32)30-9-11-34-12-10-30/h13-14H,3-12,15H2,1-2H3,(H2,25,26,27)/t24-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207217
PNG
(US9260439, 194 | US9260439, 238 | US9260439, 239)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C24H34N8O3/c1-23(2,3)35-22(33)31-8-6-24(4,15-31)32-7-5-17-18(16-13-26-20(25)27-14-16)28-21(29-19(17)32)30-9-11-34-12-10-30/h13-14H,5-12,15H2,1-4H3,(H2,25,26,27)/t24-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207217
PNG
(US9260439, 194 | US9260439, 238 | US9260439, 239)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1/C24H34N8O3/c1-23(2,3)35-22(33)31-8-6-24(4,15-31)32-7-5-17-18(16-13-26-20(25)27-14-16)28-21(29-19(17)32)30-9-11-34-12-10-30/h13-14H,5-12,15H2,1-4H3,(H2,25,26,27)/t24-/s2
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207378
PNG
(US9260439, 262)
Show SMILES CC(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H32N8O2/c1-15(2)20(32)30-7-5-23(3,14-30)31-6-4-17-18(16-12-25-21(24)26-13-16)27-22(28-19(17)31)29-8-10-33-11-9-29/h12-13,15H,4-11,14H2,1-3H3,(H2,24,25,26)/t23-/m0/s1
PDB

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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207380
PNG
(US9260439, 264)
Show SMILES CC(C)(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H34N8O2/c1-23(2,3)20(33)31-8-6-24(4,15-31)32-7-5-17-18(16-13-26-21(25)27-14-16)28-22(29-19(17)32)30-9-11-34-12-10-30/h13-14H,5-12,15H2,1-4H3,(H2,25,26,27)/t24-/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207394
PNG
(US9260439, 278)
Show SMILES COC(C)(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H34N8O3/c1-23(2,34-4)20(33)31-8-6-24(3,15-31)32-7-5-17-18(16-13-26-21(25)27-14-16)28-22(29-19(17)32)30-9-11-35-12-10-30/h13-14H,5-12,15H2,1-4H3,(H2,25,26,27)/t24-/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207406
PNG
(US9260439, 290 | US9260439, 291)
Show SMILES CCC(C)(N)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H35N9O2/c1-4-24(3,26)20(34)32-8-6-23(2,15-32)33-7-5-17-18(16-13-27-21(25)28-14-16)29-22(30-19(17)33)31-9-11-35-12-10-31/h13-14H,4-12,15,26H2,1-3H3,(H2,25,27,28)/t23-,24?/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207406
PNG
(US9260439, 290 | US9260439, 291)
Show SMILES CCC(C)(N)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H35N9O2/c1-4-24(3,26)20(34)32-8-6-23(2,15-32)33-7-5-17-18(16-13-27-21(25)28-14-16)29-22(30-19(17)33)31-9-11-35-12-10-31/h13-14H,4-12,15,26H2,1-3H3,(H2,25,27,28)/t23-,24?/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207408
PNG
(US9260439, 292)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@H](N)CF)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C22H30FN9O2/c1-22(3-5-31(13-22)19(33)16(24)10-23)32-4-2-15-17(14-11-26-20(25)27-12-14)28-21(29-18(15)32)30-6-8-34-9-7-30/h11-12,16H,2-10,13,24H2,1H3,(H2,25,26,27)/t16-,22+/m1/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207410
PNG
(US9260439, 294 | US9260439, 295)
Show SMILES CC(N)(CF)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H32FN9O2/c1-22(4-6-32(14-22)19(34)23(2,26)13-24)33-5-3-16-17(15-11-27-20(25)28-12-15)29-21(30-18(16)33)31-7-9-35-10-8-31/h11-12H,3-10,13-14,26H2,1-2H3,(H2,25,27,28)/t22-,23?/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207410
PNG
(US9260439, 294 | US9260439, 295)
Show SMILES CC(N)(CF)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H32FN9O2/c1-22(4-6-32(14-22)19(34)23(2,26)13-24)33-5-3-16-17(15-11-27-20(25)28-12-15)29-21(30-18(16)33)31-7-9-35-10-8-31/h11-12H,3-10,13-14,26H2,1-2H3,(H2,25,27,28)/t22-,23?/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207412
PNG
(US9260439, 296)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@@H](N)C1CC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O2/c1-24(5-7-32(14-24)21(34)18(25)15-2-3-15)33-6-4-17-19(16-12-27-22(26)28-13-16)29-23(30-20(17)33)31-8-10-35-11-9-31/h12-13,15,18H,2-11,14,25H2,1H3,(H2,26,27,28)/t18-,24-/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207414
PNG
(US9260439, 298)
Show SMILES CNCC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C22H31N9O2/c1-22(4-6-30(14-22)17(32)13-24-2)31-5-3-16-18(15-11-25-20(23)26-12-15)27-21(28-19(16)31)29-7-9-33-10-8-29/h11-12,24H,3-10,13-14H2,1-2H3,(H2,23,25,26)/t22-/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207415
PNG
(US9260439, 299)
Show SMILES CN(C)CC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H33N9O2/c1-23(5-7-31(15-23)18(33)14-29(2)3)32-6-4-17-19(16-12-25-21(24)26-13-16)27-22(28-20(17)32)30-8-10-34-11-9-30/h12-13H,4-11,14-15H2,1-3H3,(H2,24,25,26)/t23-/m0/s1
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PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207420
PNG
(US9260439, 304)
Show SMILES CN(C)C(C)(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C25H37N9O2/c1-24(2,31(4)5)21(35)33-9-7-25(3,16-33)34-8-6-18-19(17-14-27-22(26)28-15-17)29-23(30-20(18)34)32-10-12-36-13-11-32/h14-15H,6-13,16H2,1-5H3,(H2,26,27,28)/t25-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207422
PNG
(US9260439, 306)
Show SMILES CNCC(C)(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C25H37N9O2/c1-24(2,15-27-4)21(35)33-8-6-25(3,16-33)34-7-5-18-19(17-13-28-22(26)29-14-17)30-23(31-20(18)34)32-9-11-36-12-10-32/h13-14,27H,5-12,15-16H2,1-4H3,(H2,26,28,29)/t25-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207423
PNG
(US9260439, 307)
Show SMILES C[C@@]1(CCN(C1)C(=O)C(F)(F)CN)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C22H29F2N9O2/c1-21(3-5-32(13-21)18(34)22(23,24)12-25)33-4-2-15-16(14-10-27-19(26)28-11-14)29-20(30-17(15)33)31-6-8-35-9-7-31/h10-11H,2-9,12-13,25H2,1H3,(H2,26,27,28)/t21-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207430
PNG
(US9260439, 314)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@H](N)C(F)(F)F)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C22H28F3N9O2/c1-21(3-5-33(12-21)18(35)16(26)22(23,24)25)34-4-2-14-15(13-10-28-19(27)29-11-13)30-20(31-17(14)34)32-6-8-36-9-7-32/h10-11,16H,2-9,12,26H2,1H3,(H2,27,28,29)/t16-,21-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207431
PNG
(US9260439, 315 | US9260439, 316 | US9260439, 317)
Show SMILES CC(C(N)=O)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-14(18(24)33)20(34)31-6-4-23(2,13-31)32-5-3-16-17(15-11-26-21(25)27-12-15)28-22(29-19(16)32)30-7-9-35-10-8-30/h11-12,14H,3-10,13H2,1-2H3,(H2,24,33)(H2,25,26,27)/t14?,23-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207431
PNG
(US9260439, 315 | US9260439, 316 | US9260439, 317)
Show SMILES CC(C(N)=O)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-14(18(24)33)20(34)31-6-4-23(2,13-31)32-5-3-16-17(15-11-26-21(25)27-12-15)28-22(29-19(16)32)30-7-9-35-10-8-30/h11-12,14H,3-10,13H2,1-2H3,(H2,24,33)(H2,25,26,27)/t14?,23-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207438
PNG
(US9260439, 322)
Show SMILES CCOC(=O)C(C)(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C26H36N8O4/c1-5-38-22(36)25(2,3)21(35)33-9-7-26(4,16-33)34-8-6-18-19(17-14-28-23(27)29-15-17)30-24(31-20(18)34)32-10-12-37-13-11-32/h14-15H,5-13,16H2,1-4H3,(H2,27,28,29)/t26-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207439
PNG
(US9260439, 323)
Show SMILES C[C@@]1(CCN(C1)C(=O)CC1CC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O2/c1-24(5-7-31(15-24)19(33)12-16-2-3-16)32-6-4-18-20(17-13-26-22(25)27-14-17)28-23(29-21(18)32)30-8-10-34-11-9-30/h13-14,16H,2-12,15H2,1H3,(H2,25,26,27)/t24-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207445
PNG
(US9260439, 329)
Show SMILES CC1(CC1)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O2/c1-23(4-5-23)20(33)31-8-6-24(2,15-31)32-7-3-17-18(16-13-26-21(25)27-14-16)28-22(29-19(17)32)30-9-11-34-12-10-30/h13-14H,3-12,15H2,1-2H3,(H2,25,26,27)/t24-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207447
PNG
(US9260439, 331)
Show SMILES C[C@@]1(CCN(C1)C(=O)C1(F)CC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H29FN8O2/c1-22(5-7-31(14-22)19(33)23(24)3-4-23)32-6-2-16-17(15-12-26-20(25)27-13-15)28-21(29-18(16)32)30-8-10-34-11-9-30/h12-13H,2-11,14H2,1H3,(H2,25,26,27)/t22-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207448
PNG
(US9260439, 332)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@H]1C[C@@H]1F)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H29FN8O2/c1-23(3-5-31(13-23)20(33)16-10-17(16)24)32-4-2-15-18(14-11-26-21(25)27-12-14)28-22(29-19(15)32)30-6-8-34-9-7-30/h11-12,16-17H,2-10,13H2,1H3,(H2,25,26,27)/t16-,17-,23-/m0/s1
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207449
PNG
(US9260439, 333)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@@H]1C[C@H]1F)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H29FN8O2/c1-23(3-5-31(13-23)20(33)16-10-17(16)24)32-4-2-15-18(14-11-26-21(25)27-12-14)28-22(29-19(15)32)30-6-8-34-9-7-30/h11-12,16-17H,2-10,13H2,1H3,(H2,25,26,27)/t16-,17-,23+/m1/s1
PDB

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antibodypedia
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207451
PNG
(US9260439, 335)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@H]1C[C@H]1F)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H29FN8O2/c1-23(3-5-31(13-23)20(33)16-10-17(16)24)32-4-2-15-18(14-11-26-21(25)27-12-14)28-22(29-19(15)32)30-6-8-34-9-7-30/h11-12,16-17H,2-10,13H2,1H3,(H2,25,26,27)/t16-,17+,23-/m0/s1
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antibodypedia
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207453
PNG
(US9260439, 337)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@@H]1CC1(F)F)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H28F2N8O2/c1-22(3-5-32(13-22)19(34)16-10-23(16,24)25)33-4-2-15-17(14-11-27-20(26)28-12-14)29-21(30-18(15)33)31-6-8-35-9-7-31/h11-12,16H,2-10,13H2,1H3,(H2,26,27,28)/t16-,22-/m0/s1
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207457
PNG
(US9260439, 341)
Show SMILES C[C@@]1(CCN(C1)C(=O)C1CCC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O2/c1-24(6-8-31(15-24)21(33)16-3-2-4-16)32-7-5-18-19(17-13-26-22(25)27-14-17)28-23(29-20(18)32)30-9-11-34-12-10-30/h13-14,16H,2-12,15H2,1H3,(H2,25,26,27)/t24-/m0/s1
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PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207468
PNG
(US9260439, 352)
Show SMILES C[C@@]1(CCN(C1)C(=O)C1(F)CNC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H30FN9O2/c1-22(3-5-32(14-22)19(34)23(24)12-26-13-23)33-4-2-16-17(15-10-27-20(25)28-11-15)29-21(30-18(16)33)31-6-8-35-9-7-31/h10-11,26H,2-9,12-14H2,1H3,(H2,25,27,28)/t22-/m0/s1
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PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207476
PNG
(US9260439, 360)
Show SMILES C[C@@]1(CCN(C1)C(=O)N1CCC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O2/c1-23(4-8-31(15-23)22(33)30-5-2-6-30)32-7-3-17-18(16-13-25-20(24)26-14-16)27-21(28-19(17)32)29-9-11-34-12-10-29/h13-14H,2-12,15H2,1H3,(H2,24,25,26)/t23-/m0/s1
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PFIZER INC.

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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207483
PNG
(US9260439, 367)
Show SMILES COC1CN(C1)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-24(4-6-31(15-24)23(34)32-13-17(14-32)35-2)33-5-3-18-19(16-11-26-21(25)27-12-16)28-22(29-20(18)33)30-7-9-36-10-8-30/h11-12,17H,3-10,13-15H2,1-2H3,(H2,25,26,27)/t24-/m0/s1
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Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207485
PNG
(US9260439, 369)
Show SMILES CC1(O)CN(C1)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-23(4-6-31(13-23)22(34)32-14-24(2,35)15-32)33-5-3-17-18(16-11-26-20(25)27-12-16)28-21(29-19(17)33)30-7-9-36-10-8-30/h11-12,35H,3-10,13-15H2,1-2H3,(H2,25,26,27)/t23-/m0/s1
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PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207498
PNG
(US9260439, 382)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@H]1CCCN1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O2/c1-24(5-8-32(15-24)21(34)18-3-2-6-26-18)33-7-4-17-19(16-13-27-22(25)28-14-16)29-23(30-20(17)33)31-9-11-35-12-10-31/h13-14,18,26H,2-12,15H2,1H3,(H2,25,27,28)/t18-,24+/m1/s1
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207499
PNG
(US9260439, 383)
Show SMILES C[C@@]1(CCN(C1)C(=O)[C@]1(F)CCNC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C24H32FN9O2/c1-23(4-7-33(15-23)20(35)24(25)3-5-27-14-24)34-6-2-17-18(16-12-28-21(26)29-13-16)30-22(31-19(17)34)32-8-10-36-11-9-32/h12-13,27H,2-11,14-15H2,1H3,(H2,26,28,29)/t23-,24-/m0/s1
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<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


Citation and Details
More data for this
Ligand-Target Pair
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