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Compile Data Set for Download or QSAR

Found 27 hits of ic50 data for complexid = 50004103,50004308   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p53-MDM4


(Homo sapiens (Human))
BDBM236279
PNG
(US9365576, 32)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1/C32H31Cl2N3O3/c1-17(2)36-27(24-14-20(31(38)35-5)8-12-28(24)40-6)16-25-30(36)29(23-11-10-21(33)13-19(23)4)37(32(25)39)26-15-22(34)9-7-18(26)3/h7-17,29H,1-6H3,(H,35,38)/t29-/s2
PDB

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UniChem
US Patent
n/an/a 264n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236284
PNG
(US9365576, 37)
Show SMILES COc1ccc(cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)NOCCO
Show InChI InChI=1/C32H31Cl2N3O5/c1-18(2)36-27(24-15-21(8-12-28(24)41-4)31(39)35-42-14-13-38)17-25-30(36)29(20-6-10-22(33)11-7-20)37(32(25)40)26-16-23(34)9-5-19(26)3/h5-12,15-18,29,38H,13-14H2,1-4H3,(H,35,39)
PDB

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US Patent
n/an/a 327n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236257
PNG
(US9365576, 10)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C
Show InChI InChI=1/C31H29Cl2N3O3/c1-17(2)35-26(23-14-20(30(37)34-4)9-13-27(23)39-5)16-24-29(35)28(19-7-11-21(32)12-8-19)36(31(24)38)25-15-22(33)10-6-18(25)3/h6-17,28H,1-5H3,(H,34,37)
PDB

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US Patent
n/an/a 478n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236254
PNG
(US9365576, 7)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1/C31H28Cl2FN3O3/c1-16(2)36-25(21-14-18(30(38)35-4)9-12-26(21)40-5)15-22-29(36)28(20-11-10-19(32)13-17(20)3)37(31(22)39)24-8-6-7-23(33)27(24)34/h6-16,28H,1-5H3,(H,35,38)/t28-/s2
PDB

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n/an/a 508n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236414
PNG
(US9365576, 167)
Show SMILES COc1nc(ncc1-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c[nH]c1=O)N(C)C
Show InChI InChI=1/C28H26ClN7O3/c1-15(2)35-21(20-14-32-28(34(3)4)33-26(20)39-5)11-19-24(35)23(17-8-6-16(12-30)7-9-17)36(27(19)38)22-10-18(29)13-31-25(22)37/h6-11,13-15,23H,1-5H3,(H,31,37)/t23-/s2
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US Patent
n/an/a 717n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236368
PNG
(US9365576, 121 | US9365576, 218)
Show SMILES COc1ncc(-c2cc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)c(=O)n(C)c2)c(OC)n1
Show InChI InChI=1/C27H25Cl2N5O4/c1-14(2)33-21(19-12-30-27(38-5)31-24(19)37-4)11-18-23(33)22(15-6-8-16(28)9-7-15)34(25(18)35)17-10-20(29)26(36)32(3)13-17/h6-14,22H,1-5H3/t22-/s2
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PC sid
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US Patent
n/an/a 1.06E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM238901
PNG
(US9403827, 3)
Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1/C29H28Cl2N4O2/c1-16(2)34-26-25(21-13-12-19(30)14-18(21)4)35(23-15-20(31)11-10-17(23)3)29(36)33-27(26)32-28(34)22-8-6-7-9-24(22)37-5/h6-16,25H,1-5H3,(H,33,36)
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US Patent
n/an/a 1.45E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM238899
PNG
(US9403827, 1)
Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F
Show InChI InChI=1/C27H23Cl2FN4O2/c1-15(2)33-24-23(16-11-13-17(28)14-12-16)34(20-9-6-8-19(29)22(20)30)27(35)32-25(24)31-26(33)18-7-4-5-10-21(18)36-3/h4-15,23H,1-3H3,(H,32,35)
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US Patent
n/an/a 1.51E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM238900
PNG
(US9403827, 2)
Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1/C28H25Cl2FN4O2/c1-15(2)34-25-24(18-13-12-17(29)14-16(18)3)35(21-10-7-9-20(30)23(21)31)28(36)33-26(25)32-27(34)19-8-5-6-11-22(19)37-4/h5-15,24H,1-4H3,(H,33,36)
PDB

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US Patent
n/an/a 2.13E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236349
PNG
(US9365576, 102)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C31H36ClN3O4/c1-17(2)34-26(24-15-19(30(37)33-4)6-13-27(24)39-5)16-25-29(34)28(23-12-7-20(32)14-18(23)3)35(31(25)38)21-8-10-22(36)11-9-21/h6-7,12-17,21-22,28,36H,8-11H2,1-5H3,(H,33,37)/t21-,22-,28?
PDB

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PC sid
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US Patent
n/an/a 2.38E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236249
PNG
(US9365576, 2)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1/C31H28Cl2FN3O3/c1-16(2)36-25(21-14-18(30(38)35-4)9-12-26(21)40-5)15-22-29(36)28(20-11-10-19(32)13-17(20)3)37(31(22)39)24-8-6-7-23(33)27(24)34/h6-16,28H,1-5H3,(H,35,38)
PDB

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US Patent
n/an/a 2.90E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236348
PNG
(US9365576, 101)
Show SMILES COc1ccccc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C29H33ClN2O3/c1-17(2)31-25(23-7-5-6-8-26(23)35-4)16-24-28(31)27(22-14-9-19(30)15-18(22)3)32(29(24)34)20-10-12-21(33)13-11-20/h5-9,14-17,20-21,27,33H,10-13H2,1-4H3/t20-,21-,27?
PDB

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US Patent
n/an/a 2.99E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236354
PNG
(US9365576, 107)
Show SMILES CNC(=O)N1CCC(CC1)N1C(c2c(cc(-c3cnc(OC)nc3OC)n2C(C)C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C28H33ClN6O4/c1-16(2)34-22(21-15-31-27(39-5)32-25(21)38-4)14-20-24(34)23(17-6-8-18(29)9-7-17)35(26(20)36)19-10-12-33(13-11-19)28(37)30-3/h6-9,14-16,19,23H,10-13H2,1-5H3,(H,30,37)
PDB

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US Patent
n/an/a 3.64E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236256
PNG
(US9365576, 9)
Show SMILES COc1ccccc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C
Show InChI InChI=1/C29H26Cl2N2O2/c1-17(2)32-25(22-7-5-6-8-26(22)35-4)16-23-28(32)27(19-10-13-20(30)14-11-19)33(29(23)34)24-15-21(31)12-9-18(24)3/h5-17,27H,1-4H3
PDB

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PC sid
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US Patent
n/an/a 4.03E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236350
PNG
(US9365576, 103)
Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2C)[C@H]2CC[C@H](O)CC2)c(OC)n1
Show InChI InChI=1/C28H33ClN4O4/c1-15(2)32-23(22-14-30-28(37-5)31-26(22)36-4)13-21-25(32)24(20-11-6-17(29)12-16(20)3)33(27(21)35)18-7-9-19(34)10-8-18/h6,11-15,18-19,24,34H,7-10H2,1-5H3/t18-,19-,24?
PDB

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PC sid
UniChem
US Patent
n/an/a 4.71E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236352
PNG
(US9365576, 105)
Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2C)C2CCOCC2)c(OC)n1
Show InChI InChI=1/C27H31ClN4O4/c1-15(2)31-22(21-14-29-27(35-5)30-25(21)34-4)13-20-24(31)23(19-7-6-17(28)12-16(19)3)32(26(20)33)18-8-10-36-11-9-18/h6-7,12-15,18,23H,8-11H2,1-5H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.29E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236315
PNG
(US9365576, 68)
Show SMILES COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H30ClN5O3/c1-14(2)31-21(20-13-29-26(28)30-24(20)35-3)12-19-23(31)22(15-4-6-16(27)7-5-15)32(25(19)34)17-8-10-18(33)11-9-17/h4-7,12-14,17-18,22,33H,8-11H2,1-3H3,(H2,28,29,30)/t17-,18-,22?
PDB

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US Patent
n/an/a 7.86E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236312
PNG
(US9365576, 65)
Show SMILES COc1ccc(cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)[C@H]1CC[C@H](O)CC1)C(O)=O
Show InChI InChI=1/C29H31ClN2O5/c1-16(2)31-24(22-14-18(29(35)36)6-13-25(22)37-3)15-23-27(31)26(17-4-7-19(30)8-5-17)32(28(23)34)20-9-11-21(33)12-10-20/h4-8,13-16,20-21,26,33H,9-12H2,1-3H3,(H,35,36)/t20-,21-,26?
PDB

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US Patent
n/an/a 8.79E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236355
PNG
(US9365576, 108)
Show SMILES COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)C1CCC(=O)N(C)C1
Show InChI InChI=1/C26H29ClN6O3/c1-14(2)32-20(19-12-29-26(28)30-24(19)36-4)11-18-23(32)22(15-5-7-16(27)8-6-15)33(25(18)35)17-9-10-21(34)31(3)13-17/h5-8,11-12,14,17,22H,9-10,13H2,1-4H3,(H2,28,29,30)
PDB

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PC sid
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US Patent
n/an/a 9.02E+3n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236325
PNG
(US9365576, 78)
Show SMILES COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)C1CCOCC1
Show InChI InChI=1/C25H28ClN5O3/c1-14(2)30-20(19-13-28-25(27)29-23(19)33-3)12-18-22(30)21(15-4-6-16(26)7-5-15)31(24(18)32)17-8-10-34-11-9-17/h4-7,12-14,17,21H,8-11H2,1-3H3,(H2,27,28,29)
PDB

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PC sid
UniChem
US Patent
n/an/a 1.40E+4n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM238904
PNG
(US9403827, 6)
Show SMILES COc1ccncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F
Show InChI InChI=1/C26H22Cl2FN5O2/c1-14(2)33-23-22(15-7-9-16(27)10-8-15)34(19-6-4-5-18(28)21(19)29)26(35)32-24(23)31-25(33)17-13-30-12-11-20(17)36-3/h4-14,22H,1-3H3,(H,32,35)
PDB

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PC sid
UniChem
US Patent
n/an/a 1.40E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM238902
PNG
(US9403827, 4)
Show SMILES COc1ccncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1/C28H27Cl2N5O2/c1-15(2)34-25-24(20-9-8-18(29)12-17(20)4)35(22-13-19(30)7-6-16(22)3)28(36)33-26(25)32-27(34)21-14-31-11-10-23(21)37-5/h6-15,24H,1-5H3,(H,33,36)
PDB

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UniChem
US Patent
n/an/a 1.67E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...


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More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236248
PNG
(US9365576, 1)
Show SMILES COc1ccccc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1/C29H25Cl2FN2O2/c1-16(2)33-24(20-8-5-6-11-25(20)36-4)15-21-28(33)27(19-13-12-18(30)14-17(19)3)34(29(21)35)23-10-7-9-22(31)26(23)32/h5-16,27H,1-4H3
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US Patent
n/an/a 2.78E+4n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236250
PNG
(US9365576, 3)
Show SMILES COc1ccc(F)cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1/C29H24Cl2F2N2O2/c1-15(2)34-24(20-13-18(32)9-11-25(20)37-4)14-21-28(34)27(19-10-8-17(30)12-16(19)3)35(29(21)36)23-7-5-6-22(31)26(23)33/h5-15,27H,1-4H3
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US Patent
n/an/a 5.42E+4n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236484
PNG
(US9365576, 240)
Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C2CC2)c2ccc(Cl)cc2)c2cc(C)c(=O)n(C)c2)c(OC)n1
Show InChI InChI=1/C28H26ClN5O4/c1-15-11-19(14-32(2)26(15)35)34-23(16-5-7-17(29)8-6-16)24-20(27(34)36)12-22(33(24)18-9-10-18)21-13-30-28(38-4)31-25(21)37-3/h5-8,11-14,18,23H,9-10H2,1-4H3
PDB

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US Patent
n/an/a 7.76E+4n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236486
PNG
(US9365576, 242)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(cc(-c3ccn(C)c(=O)c3)n2C2CC2)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C28H25ClN4O3/c1-16-12-21(15-31(3)27(16)35)33-25(17-4-6-19(29)7-5-17)26-22(28(33)36)14-23(32(26)20-8-9-20)18-10-11-30(2)24(34)13-18/h4-7,10-15,20,25H,8-9H2,1-3H3
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US Patent
n/an/a>1.00E+5n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair
p53-MDM4


(Homo sapiens (Human))
BDBM236485
PNG
(US9365576, 241)
Show SMILES COc1ncc(cn1)-c1cc2C(=O)N(C(c2n1C1CC1)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1/C27H24ClN5O3/c1-15-10-20(14-31(2)25(15)34)33-23(16-4-6-18(28)7-5-16)24-21(26(33)35)11-22(32(24)19-8-9-19)17-12-29-27(36-3)30-13-17/h4-7,10-14,19,23H,8-9H2,1-3H3
PDB

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PC cid
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UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


Citation and Details
More data for this
Ligand-Target Pair