Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-coupled receptor GPR35 (Rattus norvegicus) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 61 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter ... | J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01624 BindingDB Entry DOI: 10.7270/Q2T72N8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Agonist activity at human GPR35 by Ca+2 release assay | J Med Chem 56: 7084-99 (2013) Checked by Author Article DOI: 10.1021/jm4009373 BindingDB Entry DOI: 10.7270/Q2G16280 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at GPR35 in human HT-29 cells measured after 10 mins by dynamic mass redistribution assay | ACS Med Chem Lett 3: 550-554 (2012) Article DOI: 10.1021/ml300076u BindingDB Entry DOI: 10.7270/Q2WM1FN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Corning Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay | J Med Chem 54: 7385-96 (2011) Article DOI: 10.1021/jm200999f BindingDB Entry DOI: 10.7270/Q2XG9RKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics Curated by ChEMBL | Assay Description Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay | J Med Chem 60: 362-372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay | ACS Med Chem Lett 3: 165-169 (2012) Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Corning Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay | Bioorg Med Chem Lett 22: 4148-52 (2012) Article DOI: 10.1016/j.bmcl.2012.04.057 BindingDB Entry DOI: 10.7270/Q2C53MW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response by DMR assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01624 BindingDB Entry DOI: 10.7270/Q2T72N8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics Curated by ChEMBL | Assay Description Agonist activity at GPR35 in human HT-29 cells by DMR assay | J Med Chem 60: 362-372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Mus musculus) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 980 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Agonist activity at mouse GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte... | J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.96E+3 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte... | J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Agonist activity at human GPR35 assessed as induction of beta-arrestin recruitment | ACS Med Chem Lett 9: 422-427 (2018) Article DOI: 10.1021/acsmedchemlett.7b00510 BindingDB Entry DOI: 10.7270/Q2GB26K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.24E+3 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report... | J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.52E+3 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics Curated by ChEMBL | Assay Description Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease... | J Med Chem 60: 362-372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a |
Corning Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcrip... | J Med Chem 54: 7385-96 (2011) Article DOI: 10.1021/jm200999f BindingDB Entry DOI: 10.7270/Q2XG9RKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics Curated by ChEMBL | Assay Description Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay | J Med Chem 60: 362-372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at human GPR35 expressed in U2OS cells coexpressing Gal4-VP16/beta-arrestin fusion protein after 5 hrs by tango beta-arrestin transl... | ACS Med Chem Lett 3: 550-554 (2012) Article DOI: 10.1021/ml300076u BindingDB Entry DOI: 10.7270/Q2WM1FN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactmas... | ACS Med Chem Lett 3: 165-169 (2012) Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 35 (Homo sapiens (Human)) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a |
Corning Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation af... | Bioorg Med Chem Lett 22: 4148-52 (2012) Article DOI: 10.1016/j.bmcl.2012.04.057 BindingDB Entry DOI: 10.7270/Q2C53MW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Rattus norvegicus) | BDBM14363 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL | Assay Description Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC) | J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T | |||||||||||
More data for this Ligand-Target Pair |