Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at full length human ERbeta receptor assessed as transcriptional activity incubated for 22 to 24 hrs by cell based luciferase report... | Citation and Details Article DOI: 10.1016/j.bmc.2020.115670 BindingDB Entry DOI: 10.7270/Q2ZK5MCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 480 | n/a | 0.700 | n/a | n/a | 7.4 | 22 |
Novartis Pharmaceuticals | Assay Description Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA... | J Med Chem 45: 1399-401 (2002) Article DOI: 10.1021/jm015577l BindingDB Entry DOI: 10.7270/Q27M0665 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of fluormone from GST-tagged ERbeta receptor LBD (unknown origin) measured after 60 mins by TR-FRET competitive binding assay | Citation and Details Article DOI: 10.1016/j.bmc.2020.115670 BindingDB Entry DOI: 10.7270/Q2ZK5MCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.14E+3 | n/a | 2.10 | n/a | n/a | 7.4 | 22 |
Novartis Pharmaceuticals | Assay Description Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA... | J Med Chem 45: 1399-401 (2002) Article DOI: 10.1021/jm015577l BindingDB Entry DOI: 10.7270/Q27M0665 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at full length human ERalpha receptor assessed as transcriptional activity incubated for 22 to 24 hrs by cell based luciferase repor... | Citation and Details Article DOI: 10.1016/j.bmc.2020.115670 BindingDB Entry DOI: 10.7270/Q2ZK5MCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
FIN-00014 University of Helsinki Curated by ChEMBL | Assay Description Activity at human recombinant ERalpha by fluorescence polarization assay | J Med Chem 52: 6660-71 (2009) Article DOI: 10.1021/jm900928k BindingDB Entry DOI: 10.7270/Q2RV0PMD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
FIN-00014 University of Helsinki Curated by ChEMBL | Assay Description Activity at human recombinant ERbeta by fluorescence polarization assay | J Med Chem 52: 6660-71 (2009) Article DOI: 10.1021/jm900928k BindingDB Entry DOI: 10.7270/Q2RV0PMD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at full length human ERbeta receptor assessed as inhibition of estradiol-induced activation incubated for 22 to 24 hrs by cell ba... | Citation and Details Article DOI: 10.1016/j.bmc.2020.115670 BindingDB Entry DOI: 10.7270/Q2ZK5MCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 31 | n/a | 26 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor... | J Med Chem 49: 2440-55 (2006) Article DOI: 10.1021/jm0509389 BindingDB Entry DOI: 10.7270/Q2WH2N82 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >50 | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at full length human ERalpha receptor assessed as inhibition of estradiol-induced activation incubated for 22 to 24 hrs by cell b... | Citation and Details Article DOI: 10.1016/j.bmc.2020.115670 BindingDB Entry DOI: 10.7270/Q2ZK5MCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to activate estrogen receptor 2-mediated transcription. | Bioorg Med Chem Lett 14: 2327-30 (2004) Article DOI: 10.1016/j.bmcl.2004.01.099 BindingDB Entry DOI: 10.7270/Q2HT2PVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to activate estrogen receptor 1-mediated transcription. | Bioorg Med Chem Lett 14: 2327-30 (2004) Article DOI: 10.1016/j.bmcl.2004.01.099 BindingDB Entry DOI: 10.7270/Q2HT2PVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17289 ((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 29 | n/a | 166 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor... | J Med Chem 49: 2440-55 (2006) Article DOI: 10.1021/jm0509389 BindingDB Entry DOI: 10.7270/Q2WH2N82 | |||||||||||
More data for this Ligand-Target Pair |