Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18376 ((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.80 | n/a | 1.70 | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme... | J Med Chem 51: 31-45 (2008) Article DOI: 10.1021/jm070849r BindingDB Entry DOI: 10.7270/Q2VD6WRD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18376 ((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 9.80 | n/a | 2.30 | n/a | n/a | 7.0 | 37 |
Bristol-Myers Squibb Company | Assay Description Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme... | J Med Chem 51: 2722-33 (2008) Article DOI: 10.1021/jm800001n BindingDB Entry DOI: 10.7270/Q2FT8JB2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM18376 ((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Southern Research Institute Curated by PubChem BioAssay | PubChem Bioassay (2016) BindingDB Entry DOI: 10.7270/Q2CZ35ZF | ||||||||||||
More data for this Ligand-Target Pair |