Compile Data Set for Download or QSAR

Found 7 hits of ec50 for monomerid = 196906   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Rattus norvegicus (Rat))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (Rattus norvegicus (Rat))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.92E+4	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM196906 (US9212196, Derivative 2) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.92E+4	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair