Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM20878 ((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.20 | n/a | n/a | 7.2 | 22 |
Bristol-Myers Squibb Company | Assay Description Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt... | J Med Chem 51: 1145-9 (2008) Article DOI: 10.1021/jm701272q BindingDB Entry DOI: 10.7270/Q2PN93X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM20878 ((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a |
Terns Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of SGLT2 (unknown origin) | J Med Chem 63: 5031-5073 (2020) Article DOI: 10.1021/acs.jmedchem.9b01701 BindingDB Entry DOI: 10.7270/Q2DJ5JXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (Homo sapiens (Human)) | BDBM20878 ((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >8.00E+3 | n/a | n/a | n/a | n/a |
Terns Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of SGLT1 (unknown origin) | J Med Chem 63: 5031-5073 (2020) Article DOI: 10.1021/acs.jmedchem.9b01701 BindingDB Entry DOI: 10.7270/Q2DJ5JXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (Homo sapiens (Human)) | BDBM20878 ((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >8.00E+3 | n/a | n/a | 7.2 | 22 |
Bristol-Myers Squibb Company | Assay Description Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt... | J Med Chem 51: 1145-9 (2008) Article DOI: 10.1021/jm701272q BindingDB Entry DOI: 10.7270/Q2PN93X4 | |||||||||||
More data for this Ligand-Target Pair |