Found 4 hits of ec50 for monomerid = 50031476 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50031476
(CHEMBL3358548)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 |r| Show InChI InChI=1S/C51H69N17O8/c1-3-4-15-38(59-30(2)69)45(71)61-40-18-11-22-68-28-33(66-67-68)19-20-37(44(52)70)60-49(75)42(24-32-26-57-36-16-9-8-14-35(32)36)64-46(72)39(17-10-21-56-51(53)54)62-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-47(40)73)25-34-27-55-29-58-34/h5-9,12-14,16,26-29,37-43,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,71)(H,62,74)(H,63,76)(H,64,72)(H,65,73)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a |
University of Cergy-Pontoise
Curated by ChEMBL
| Assay Description Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay |
J Med Chem 57: 9424-34 (2014)
Article DOI: 10.1021/jm501027w BindingDB Entry DOI: 10.7270/Q21G0NVT |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50031476
(CHEMBL3358548)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 |r| Show InChI InChI=1S/C51H69N17O8/c1-3-4-15-38(59-30(2)69)45(71)61-40-18-11-22-68-28-33(66-67-68)19-20-37(44(52)70)60-49(75)42(24-32-26-57-36-16-9-8-14-35(32)36)64-46(72)39(17-10-21-56-51(53)54)62-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-47(40)73)25-34-27-55-29-58-34/h5-9,12-14,16,26-29,37-43,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,71)(H,62,74)(H,63,76)(H,64,72)(H,65,73)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a |
University of Cergy-Pontoise
Curated by ChEMBL
| Assay Description Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay |
J Med Chem 57: 9424-34 (2014)
Article DOI: 10.1021/jm501027w BindingDB Entry DOI: 10.7270/Q21G0NVT |
More data for this Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50031476
(CHEMBL3358548)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 |r| Show InChI InChI=1S/C51H69N17O8/c1-3-4-15-38(59-30(2)69)45(71)61-40-18-11-22-68-28-33(66-67-68)19-20-37(44(52)70)60-49(75)42(24-32-26-57-36-16-9-8-14-35(32)36)64-46(72)39(17-10-21-56-51(53)54)62-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-47(40)73)25-34-27-55-29-58-34/h5-9,12-14,16,26-29,37-43,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,71)(H,62,74)(H,63,76)(H,64,72)(H,65,73)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
University of Cergy-Pontoise
Curated by ChEMBL
| Assay Description Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay |
J Med Chem 57: 9424-34 (2014)
Article DOI: 10.1021/jm501027w BindingDB Entry DOI: 10.7270/Q21G0NVT |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50031476
(CHEMBL3358548)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 |r| Show InChI InChI=1S/C51H69N17O8/c1-3-4-15-38(59-30(2)69)45(71)61-40-18-11-22-68-28-33(66-67-68)19-20-37(44(52)70)60-49(75)42(24-32-26-57-36-16-9-8-14-35(32)36)64-46(72)39(17-10-21-56-51(53)54)62-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-47(40)73)25-34-27-55-29-58-34/h5-9,12-14,16,26-29,37-43,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,71)(H,62,74)(H,63,76)(H,64,72)(H,65,73)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
University of Cergy-Pontoise
Curated by ChEMBL
| Assay Description Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay |
J Med Chem 57: 9424-34 (2014)
Article DOI: 10.1021/jm501027w BindingDB Entry DOI: 10.7270/Q21G0NVT |
More data for this Ligand-Target Pair | |