BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits of ec50 for monomerid = 50238083   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50238083
PNG
(CHEMBL4089166)
Show SMILES NC(=O)Cn1ncc2nccc(Nc3ccnc(c3)-c3cc(F)ccc3F)c12
Show InChI InChI=1S/C19H14F2N6O/c20-11-1-2-14(21)13(7-11)16-8-12(3-5-23-16)26-15-4-6-24-17-9-25-27(19(15)17)10-18(22)28/h1-9H,10H2,(H2,22,28)(H,23,24,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 200n/an/an/an/a



Takeda California

Curated by ChEMBL


Assay Description
Inhibition of ALK5 (unknown origin) expressed in SBE-bla HEK293T cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation by beta lacta...


Bioorg Med Chem Lett 27: 1955-1961 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.026
BindingDB Entry DOI: 10.7270/Q2QJ7KKZ
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50238083
PNG
(CHEMBL4089166)
Show SMILES NC(=O)Cn1ncc2nccc(Nc3ccnc(c3)-c3cc(F)ccc3F)c12
Show InChI InChI=1S/C19H14F2N6O/c20-11-1-2-14(21)13(7-11)16-8-12(3-5-23-16)26-15-4-6-24-17-9-25-27(19(15)17)10-18(22)28/h1-9H,10H2,(H2,22,28)(H,23,24,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.26E+3n/an/an/an/a



Takeda California

Curated by ChEMBL


Assay Description
Inhibition of ALK5 in human Calu6 cells assessed as reduction in Smad2/3 phosphorylation


Bioorg Med Chem Lett 27: 1955-1961 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.026
BindingDB Entry DOI: 10.7270/Q2QJ7KKZ
More data for this
Ligand-Target Pair