Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50266337 (12-epi-Salvinorin A | CHEMBL458235) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting | Bioorg Med Chem Lett 22: 1023-6 (2012) Article DOI: 10.1016/j.bmcl.2011.11.128 BindingDB Entry DOI: 10.7270/Q2S182X2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50266337 (12-epi-Salvinorin A | CHEMBL458235) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 84 | n/a | n/a | n/a | n/a |
McLean Hospital Curated by ChEMBL | Assay Description Agonist activity at human KOPR expressed in CHO cells assessed as enhancenment of [35S]GTPgammaS binding | Bioorg Med Chem 17: 1370-80 (2009) Article DOI: 10.1016/j.bmc.2008.12.012 BindingDB Entry DOI: 10.7270/Q25H7G4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50266337 (12-epi-Salvinorin A | CHEMBL458235) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 382 | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Agonist activity at human KOPR expressed in U2OS cells assessed as beta-arrestin2 recruitment after 90 mins by DiscoveRx PathHunter assay | Bioorg Med Chem Lett 22: 1023-6 (2012) Article DOI: 10.1016/j.bmcl.2011.11.128 BindingDB Entry DOI: 10.7270/Q2S182X2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50266337 (12-epi-Salvinorin A | CHEMBL458235) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a |
The University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as [35S]GTP-gamma-S binding after 3 hrs by liquid scintil... | Bioorg Med Chem 20: 3100-10 (2012) Article DOI: 10.1016/j.bmc.2012.02.040 BindingDB Entry DOI: 10.7270/Q27H1KK0 | |||||||||||
More data for this Ligand-Target Pair |