Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 4 [Q124R] (Rattus norvegicus) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 78.3 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2DR2SWV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux | J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor | Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 336 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2VT1QHF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization | J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Positive allosteric modulator activity at human mGlu4 receptor | Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B | |||||||||||
More data for this Ligand-Target Pair |