Found 2 hits of ec50 for monomerid = 50317583 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human)) | BDBM50317583
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)| Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Activation of PXR |
Bioorg Med Chem Lett 22: 5979-83 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.035 BindingDB Entry DOI: 10.7270/Q28P61S0 |
More data for this Ligand-Target Pair | |
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human)) | BDBM50317583
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)| Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Activation of PXR |
Bioorg Med Chem Lett 20: 2765-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.069 BindingDB Entry DOI: 10.7270/Q23T9HCC |
More data for this Ligand-Target Pair | |