Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human)) | BDBM107746 (CHEMBL2347107 | US8933095, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysis | Bioorg Med Chem Lett 23: 1961-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.039 BindingDB Entry DOI: 10.7270/Q2N87C48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human)) | BDBM107746 (CHEMBL2347107 | US8933095, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 59.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ... | US Patent US8598200 (2013) BindingDB Entry DOI: 10.7270/Q2G73CBJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human)) | BDBM107746 (CHEMBL2347107 | US8933095, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 59.4 | n/a | n/a | n/a | n/a | n/a | 37 |
Pfizer Inc. US Patent | Assay Description Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ... | US Patent US8933095 (2015) BindingDB Entry DOI: 10.7270/Q2J9653C | |||||||||||
More data for this Ligand-Target Pair |