Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM10873 (4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase | Bioorg Med Chem Lett 14: 5703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.07.085 BindingDB Entry DOI: 10.7270/Q23N22VW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM10873 (4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonam...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 2.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. US Patent | US Patent US9616064 (2017) BindingDB Entry DOI: 10.7270/Q2KD2106 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 5A, mitochondrial (Homo sapiens (Human)) | BDBM10873 (4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonam...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase | Bioorg Med Chem Lett 14: 5703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.07.085 BindingDB Entry DOI: 10.7270/Q23N22VW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM10873 (4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonam...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 3.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. US Patent | Assay Description The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti... | US Patent US9616064 (2017) BindingDB Entry DOI: 10.7270/Q2KD2106 | |||||||||||
More data for this Ligand-Target Pair |