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Compile Data Set for Download or QSAR

Found 1 hit of ic50 for monomerid = 14410   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14410
PNG
(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-met...)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(C)C1)C(C)=O
Show InChI InChI=1S/C22H28N6O3/c1-5-7-8-31-22-16(9-14(10-23-22)13(3)29)20-24-18-17(6-2)28(15-11-27(4)12-15)26-19(18)21(30)25-20/h9-10,15H,5-8,11-12H2,1-4H3,(H,24,25,30)
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MMDB

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Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair