Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14605 (1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSAR | Assay Description Abbott Kinase Enzymatics_CHK1/289 CDC25c - IC50(uM) (IC50) | CSAR 1: (2012) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14605 (1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
CSAR | Assay Description ChemBL affinity - Published Abbott papers | CSAR 1: (2012) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14605 (1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Abbott Laboratories | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor... | Bioorg Med Chem Lett 16: 2293-8 (2006) Article DOI: 10.1016/j.bmcl.2006.01.028 BindingDB Entry DOI: 10.7270/Q26971TD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) |