Found 12 hits of ic50 for monomerid = 15336 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
KEGG
UniProtKB/SwissProt
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Evaluated for Ca++ dependent phosphodiesterase activity. |
J Med Chem 33: 2240-54 (1990)
BindingDB Entry DOI: 10.7270/Q2PR7WKF |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [654-1073]
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 242 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories
| Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... |
Biochemistry 43: 6091-100 (2004)
Article DOI: 10.1021/bi049868i BindingDB Entry DOI: 10.7270/Q2DR2SQM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase [535-860]
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill
| Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... |
J Biol Chem 281: 21469-79 (2006)
Article DOI: 10.1074/jbc.M512527200 BindingDB Entry DOI: 10.7270/Q290221F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lung |
J Med Chem 28: 537-45 (1985)
BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875]
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill
| Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... |
J Biol Chem 281: 21469-79 (2006)
Article DOI: 10.1074/jbc.M512527200 BindingDB Entry DOI: 10.7270/Q290221F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Binding affinity towards the adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]CHA as radioligand. |
J Med Chem 33: 2240-54 (1990)
BindingDB Entry DOI: 10.7270/Q2PR7WKF |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of human lung |
J Med Chem 28: 537-45 (1985)
BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a/A2b
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand. |
J Med Chem 33: 2240-54 (1990)
BindingDB Entry DOI: 10.7270/Q2PR7WKF |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| PDB PubMed
| n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Chemistry
Curated by ChEMBL
| Assay Description Inhibition of PDE5 from platelets |
J Med Chem 44: 3746-9 (2001)
BindingDB Entry DOI: 10.7270/Q2H13196 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphodiesterase
(Trypanosoma cruzi) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | 7.5 | 24 |
University of North Carolina
| Assay Description Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate. |
J Biol Chem 287: 11788-97 (2012)
Article DOI: 10.1074/jbc.M111.326777 BindingDB Entry DOI: 10.7270/Q2K9364D |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875]
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill
| Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... |
J Biol Chem 281: 21469-79 (2006)
Article DOI: 10.1074/jbc.M512527200 BindingDB Entry DOI: 10.7270/Q290221F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM15336
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB MMDB
KEGG
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina
Curated by ChEMBL
| Assay Description Inhibition of human PDE9A expressed in Escherichia coli BL21 by liquid scintillation counting |
J Med Chem 53: 1726-31 (2010)
Article DOI: 10.1021/jm901519f BindingDB Entry DOI: 10.7270/Q2ST7PZH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |