Compile Data Set for Download or QSAR

Found 6 hits of ic50 for monomerid = 154190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154190 (US9012443, 199) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1 Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...				US Patent US9012443 (2015) BindingDB Entry DOI: 10.7270/Q2N0158J
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154190 (US9012443, 199) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1 Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 60: 5969-5989 (2017) Article DOI: 10.1021/acs.jmedchem.6b01851 BindingDB Entry DOI: 10.7270/Q2RJ4MS7
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154190 (US9012443, 199) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1 Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...				US Patent US9012443 (2015) BindingDB Entry DOI: 10.7270/Q2N0158J
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM154190 (US9012443, 199) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1 Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)				J Med Chem 60: 5969-5989 (2017) Article DOI: 10.1021/acs.jmedchem.6b01851 BindingDB Entry DOI: 10.7270/Q2RJ4MS7
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM154190 (US9012443, 199) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1 Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)				J Med Chem 60: 5969-5989 (2017) Article DOI: 10.1021/acs.jmedchem.6b01851 BindingDB Entry DOI: 10.7270/Q2RJ4MS7
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM154190 (US9012443, 199) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1 Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description 293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...				US Patent US9012443 (2015) BindingDB Entry DOI: 10.7270/Q2N0158J
					More data for this Ligand-Target Pair