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Compile Data Set for Download or QSAR

Found 8 hits of ic50 for monomerid = 154576   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a 800n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent protein kinase 2 variant (CDK2 C118L)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a 7.20E+3n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent protein kinase 2 (CDK2 F80M)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent protein kinase 2 (CDK2 C118I)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent protein kinase 2 variant (CDK2 A144C)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent protein kinase 2 (CDK2 A144G)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair
Cyclin-dependent protein kinase 2 (CDK2 F80T)


(Homo sapiens (Human))
BDBM154576
PNG
(K03861 (1))
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



University of Oxford



Assay Description
For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...


ACS Chem Biol 10: 2116-25 (2015)


Article DOI: 10.1021/acschembio.5b00398
BindingDB Entry DOI: 10.7270/Q2VH5MKH
More data for this
Ligand-Target Pair