Compile Data Set for Download or QSAR

Found 8 hits of ic50 for monomerid = 160076   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assay				Bioorg Med Chem Lett 26: 257-61 (2016) Article DOI: 10.1016/j.bmcl.2015.12.052 BindingDB Entry DOI: 10.7270/Q2MW2K0Z
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...				US Patent US10047092 (2018) BindingDB Entry DOI: 10.7270/Q27D2X4N
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US10053463 (2018) BindingDB Entry DOI: 10.7270/Q2FT8P24
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...				US Patent US9040534 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P6W
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...				US Patent US10047092 (2018) BindingDB Entry DOI: 10.7270/Q27D2X4N
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Mus musculus)	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US10053463 (2018) BindingDB Entry DOI: 10.7270/Q2FT8P24
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...				US Patent US9040534 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P6W
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM160076 (US10047092, 17 | US10053463, 17 | US9040534, 17) Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H15ClF4N4O/c1-11-9-29-17(12-5-7-14(22)8-6-12)26-27-18(29)19(30)28(11)10-13-3-2-4-15(16(13)21)20(23,24)25/h2-8,11H,9-10H2,1H3/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assay				Bioorg Med Chem Lett 26: 257-61 (2016) Article DOI: 10.1016/j.bmcl.2015.12.052 BindingDB Entry DOI: 10.7270/Q2MW2K0Z
					More data for this Ligand-Target Pair