Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom... | Citation and Details BindingDB Entry DOI: 10.7270/Q2H70KFJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT US Patent | Assay Description Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f... | US Patent US10870618 (2020) BindingDB Entry DOI: 10.7270/Q2HD7ZRH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) BindingDB Entry DOI: 10.7270/Q2M048J6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498] (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2445RM9 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 727 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured... | Citation and Details BindingDB Entry DOI: 10.7270/Q2H70KFJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2445RM9 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498] (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) BindingDB Entry DOI: 10.7270/Q2M048J6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2445RM9 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2/Nuclear receptor corepressor 2 [395-498] (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida College of Medicine; Northwest Agriculture and Forestry University | Assay Description Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ... | Chem Biol 22: 273-84 (2015) Article DOI: 10.1016/j.chembiol.2014.12.015 BindingDB Entry DOI: 10.7270/Q2TX3D48 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM163623 (SR-3206 | US10807944, Compound RLS2-126 | US108706...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Research Foundation, Inc.; The Scripps Research Institute US Patent | Assay Description These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic... | US Patent US10807944 (2020) BindingDB Entry DOI: 10.7270/Q2M048J6 | |||||||||||
More data for this Ligand-Target Pair |