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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 186819   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]


(Homo sapiens (Human))
BDBM186819
PNG
(US9670203, Compound 1.11)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H18F4N4O4/c26-12-7-11(25(27,28)29)8-13(9-12)31-24(35)33-21-20-16-10-14(1-3-17(16)37-22(20)21)36-18-5-6-30-23-15(18)2-4-19(34)32-23/h1,3,5-10,20-22H,2,4H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80E+3n/an/an/an/an/a25



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)


BindingDB Entry DOI: 10.7270/Q20Z71F5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E]


(Homo sapiens (Human))
BDBM186819
PNG
(US9670203, Compound 1.11)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H18F4N4O4/c26-12-7-11(25(27,28)29)8-13(9-12)31-24(35)33-21-20-16-10-14(1-3-17(16)37-22(20)21)36-18-5-6-30-23-15(18)2-4-19(34)32-23/h1,3,5-10,20-22H,2,4H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)


BindingDB Entry DOI: 10.7270/Q20Z71F5
More data for this
Ligand-Target Pair