Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Aromatase (Homo sapiens (Human)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.00110 | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Institute of Medicinal and Aromatic Plants | Assay Description Inhibition assay using aromatase enzyme. | Chem Biol Drug Des 80: 616-624 (2012) Article DOI: 10.1111/j.1747-0285.2012.01439.x BindingDB Entry DOI: 10.7270/Q24X56CG | |||||||||||
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Dipeptidyl peptidase 4 (Sus scrofa (pig)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of porcine DPP4 after 30 mins by luminescence assay | Eur J Med Chem 151: 145-157 (2018) Article DOI: 10.1016/j.ejmech.2018.03.041 BindingDB Entry DOI: 10.7270/Q2CZ39SV | |||||||||||
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Estrogen receptor beta (Homo sapiens (Human)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Ghent University | Assay Description Ligand binding was determined using a scintillation proximity assay with streptavidin-coated polyvinyltoluene scintillation beads (Amersham) and biot... | J Med Chem 49: 7357-65 (2006) Article DOI: 10.1021/jm060692n BindingDB Entry DOI: 10.7270/Q2M61HJ1 | |||||||||||
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Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmcl.2022.128574 BindingDB Entry DOI: 10.7270/Q22J6GXX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmcl.2022.128574 BindingDB Entry DOI: 10.7270/Q22J6GXX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.23E+4 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Ghent University | Assay Description Ligand binding was determined using a scintillation proximity assay with streptavidin-coated polyvinyltoluene scintillation beads (Amersham) and biot... | J Med Chem 49: 7357-65 (2006) Article DOI: 10.1021/jm060692n BindingDB Entry DOI: 10.7270/Q2M61HJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldehyde oxidase 1 (Cavia porcellus (Guinea pig)) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.48E+5 | n/a | 2.12E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Kermanshah University of Medical Sciences | Assay Description Guinea pig AO activity was assayed spectrophotometrically using phenanthridine as a substrate at 322 nm. All spectrophotometric determinations were c... | Bioorg Chem 64: 74-84 (2016) Article DOI: 10.1016/j.bioorg.2015.12.004 BindingDB Entry DOI: 10.7270/Q2MP522Q | |||||||||||
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Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...) | BDBM19461 (α-CA inhibitor, 5 | 5,7-dihydroxy-2-(4-hydrox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.28E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Jishou University Curated by ChEMBL | Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol method | Eur J Med Chem 63: 685-95 (2013) Article DOI: 10.1016/j.ejmech.2013.03.016 BindingDB Entry DOI: 10.7270/Q2D79FB1 | |||||||||||
More data for this Ligand-Target Pair |