Compile Data Set for Download or QSAR

Found 1 hit of ic50 for monomerid = 21908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM21908 (4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...) Show SMILES OCC(O)COc1cc(NCc2cnc[nH]2)cc2c(Nc3ccc(F)c(Cl)c3)c(cnc12)C#N Show InChI InChI=1S/C23H20ClFN6O3/c24-19-4-14(1-2-20(19)25)31-22-13(6-26)7-29-23-18(22)3-15(28-9-16-8-27-12-30-16)5-21(23)34-11-17(33)10-32/h1-5,7-8,12,17,28,32-33H,9-11H2,(H,27,30)(H,29,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	7.2	30
Wyeth Research					Assay Description Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...				J Med Chem 50: 4728-45 (2007) Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441
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