Compile Data Set for Download or QSAR

Found 1 hit of ic50 for monomerid = 21917   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM21917 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[({5...) Show SMILES CC(C)N1CCC(O)(CC1)c1cncc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)c1 Show InChI InChI=1S/C30H29Cl2FN6O/c1-18(2)39-7-5-30(40,6-8-39)21-9-19(14-35-17-21)15-36-23-10-24-28(38-22-3-4-27(33)25(31)11-22)20(13-34)16-37-29(24)26(32)12-23/h3-4,9-12,14,16-18,36,40H,5-8,15H2,1-2H3,(H,37,38)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	7.2	30
Wyeth Research					Assay Description Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...				J Med Chem 50: 4728-45 (2007) Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441
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