BindingDB PrimarySearch

Found 15 hits of ic50 for monomerid = 22874
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of histamine H1 receptor (unknown origin)				J Med Chem 58: 2584-608 (2015) Article DOI: 10.1021/jm501535r BindingDB Entry DOI: 10.7270/Q2JM2CBK
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma. Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting				Bioorg Med Chem 19: 3005-21 (2011) Article DOI: 10.1016/j.bmc.2011.03.003 BindingDB Entry DOI: 10.7270/Q23T9HJM
Dainippon Sumitomo Pharma. Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Phrama. Co. Ltd Curated by ChEMBL					Assay Description Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting				Bioorg Med Chem Lett 19: 2766-71 (2009) Article DOI: 10.1016/j.bmcl.2009.03.124 BindingDB Entry DOI: 10.7270/Q2GM87BK
Dainippon Sumitomo Phrama. Co. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Phrama. Co. Ltd Curated by ChEMBL					Assay Description Inhibition of histamine H1 receptor				Bioorg Med Chem Lett 19: 2766-71 (2009) Article DOI: 10.1016/j.bmcl.2009.03.124 BindingDB Entry DOI: 10.7270/Q2GM87BK
Dainippon Sumitomo Phrama. Co. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of human ERG in L929 cells by whole cell patch-clamp assay				Bioorg Med Chem Lett 19: 5043-7 (2009) Article DOI: 10.1016/j.bmcl.2009.07.047 BindingDB Entry DOI: 10.7270/Q2NP24HJ
The Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
CASMedChem Laboratory Curated by ChEMBL					Assay Description Inhibition of human ERG in MCF7 cells				Eur J Med Chem 44: 1926-32 (2009) Article DOI: 10.1016/j.ejmech.2008.11.009 BindingDB Entry DOI: 10.7270/Q2TM7CCD
CASMedChem Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state				Bioorg Med Chem Lett 15: 1737-41 (2005) Article DOI: 10.1016/j.bmcl.2005.01.008 BindingDB Entry DOI: 10.7270/Q2FT8NCR
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1				J Med Chem 45: 3844-53 (2002) BindingDB Entry DOI: 10.7270/Q2NC61X3
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
TCG Lifesciences Ltd. Curated by ChEMBL					Assay Description Inhibition of human ERG				Eur J Med Chem 46: 618-30 (2011) Article DOI: 10.1016/j.ejmech.2010.11.042 BindingDB Entry DOI: 10.7270/Q2WQ052W
TCG Lifesciences Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1				Bioorg Med Chem Lett 13: 1829-35 (2003) BindingDB Entry DOI: 10.7270/Q2TX3FX0
Aventis Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Portola Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay				Bioorg Med Chem Lett 16: 5507-12 (2006) Article DOI: 10.1016/j.bmcl.2006.08.039 BindingDB Entry DOI: 10.7270/Q2SF2X05
Portola Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen San Francisco Curated by ChEMBL					Assay Description Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis				Bioorg Med Chem Lett 22: 3781-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.006 BindingDB Entry DOI: 10.7270/Q2542PMN
Amgen San Francisco Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2J2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tongji University Curated by ChEMBL					Assay Description Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method				Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G
Tongji University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method				J Med Chem 52: 1630-8 (2009) Article DOI: 10.1021/jm801236n BindingDB Entry DOI: 10.7270/Q26M37RK
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM22874 (2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay				Bioorg Med Chem Lett 19: 5043-7 (2009) Article DOI: 10.1016/j.bmcl.2009.07.047 BindingDB Entry DOI: 10.7270/Q2NP24HJ
The Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair