BindingDB PrimarySearch

Found 25 hits of ic50 for monomerid = 25117
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Fuzhou University Curated by ChEMBL					Assay Description Inhibition of VEGFR1 (unknown origin)				Eur J Med Chem 179: 916-935 (2019) Article DOI: 10.1016/j.ejmech.2019.06.070 BindingDB Entry DOI: 10.7270/Q2KD224D
Fuzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Fuzhou University Curated by ChEMBL					Assay Description Inhibition of VEGFR3 (unknown origin)				Eur J Med Chem 179: 916-935 (2019) Article DOI: 10.1016/j.ejmech.2019.06.070 BindingDB Entry DOI: 10.7270/Q2KD224D
Fuzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) Curated by ChEMBL					Assay Description Inhibition of VEGFR1 (unknown origin)				Eur J Med Chem 142: 383-392 (2017) Article DOI: 10.1016/j.ejmech.2017.08.007 BindingDB Entry DOI: 10.7270/Q2WS8WZZ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) Curated by ChEMBL					Assay Description Inhibition of VEGFR3 (unknown origin)				Eur J Med Chem 142: 383-392 (2017) Article DOI: 10.1016/j.ejmech.2017.08.007 BindingDB Entry DOI: 10.7270/Q2WS8WZZ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				Eur J Med Chem 142: 383-392 (2017) Article DOI: 10.1016/j.ejmech.2017.08.007 BindingDB Entry DOI: 10.7270/Q2WS8WZZ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Fuzhou University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				Eur J Med Chem 179: 916-935 (2019) Article DOI: 10.1016/j.ejmech.2019.06.070 BindingDB Entry DOI: 10.7270/Q2KD224D
Fuzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of active wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using A...				Eur J Med Chem 160: 61-81 (2018) Article DOI: 10.1016/j.ejmech.2018.10.007 BindingDB Entry DOI: 10.7270/Q2M33062
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human VEGFR2				J Med Chem 61: 140-157 (2018) Article DOI: 10.1021/acs.jmedchem.7b01091 BindingDB Entry DOI: 10.7270/Q2GB26GX
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 45: 5420-7 (2010) Article DOI: 10.1016/j.ejmech.2010.09.002 BindingDB Entry DOI: 10.7270/Q2TX3FMZ
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	0.418	n/a	n/a	n/a	n/a	7.5	25
PFIZER INC. US Patent					Assay Description Axitinib was tested using a Z′-LYTE Screening Protocol (Invitrogen, Carlsbad, Calif.). Axitinib was prepared in 100% DMSO, and added to the rea...				US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG
PFIZER INC. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	0.551	n/a	n/a	n/a	n/a	7.5	25
PFIZER INC. US Patent					Assay Description Axitinib was tested with the Caliper LabChip3000 assay (Caliper Life Science, Hopkinton, Mass.), which is a mobility-shift assay (MSA) that combines ...				US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG
PFIZER INC. US Patent					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
SENJU PHARMACEUTICAL CO., LTD. US Patent					Assay Description Measurement of the kinase inhibitory activity of each compound produced in Examples was conducted using the Off-chip Mobility Shift Assay. For this t...				US Patent US9617222 (2017) BindingDB Entry DOI: 10.7270/Q2FN189X
SENJU PHARMACEUTICAL CO., LTD. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of inactive wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells asses...				Eur J Med Chem 160: 61-81 (2018) Article DOI: 10.1016/j.ejmech.2018.10.007 BindingDB Entry DOI: 10.7270/Q2M33062
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	25
PFIZER INC. US Patent					Assay Description Axitinib was tested using a Z′-LYTE Screening Protocol (Invitrogen, Carlsbad, Calif.). Axitinib was prepared in 100% DMSO, and added to the rea...				US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG
PFIZER INC. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	7.78	n/a	n/a	n/a	n/a	7.5	25
PFIZER INC. US Patent					Assay Description Axitinib was tested with the Caliper LabChip3000 assay (Caliper Life Science, Hopkinton, Mass.), which is a mobility-shift assay (MSA) that combines ...				US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG
PFIZER INC. US Patent					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Scientific and Innovative Research (AcSIR) Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (805 to 1356 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111609 BindingDB Entry DOI: 10.7270/Q2D2220M
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA method				J Med Chem 58: 130-46 (2015) Article DOI: 10.1021/jm500537u BindingDB Entry DOI: 10.7270/Q2125V9W
EntreMed Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
EntreMed Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of PLK-4 (unknown origin)				Eur J Med Chem 95: 35-40 (2015) Article DOI: 10.1016/j.ejmech.2015.03.020 BindingDB Entry DOI: 10.7270/Q2NG4SBV
Zhengzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of inactive wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduct...				Eur J Med Chem 160: 61-81 (2018) Article DOI: 10.1016/j.ejmech.2018.10.007 BindingDB Entry DOI: 10.7270/Q2M33062
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of active wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using ABLtide as sub...				Eur J Med Chem 160: 61-81 (2018) Article DOI: 10.1016/j.ejmech.2018.10.007 BindingDB Entry DOI: 10.7270/Q2M33062
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Technical University of Dortmund					Assay Description IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...				ACS Chem Biol 10: 289-98 (2015) Article DOI: 10.1021/cb500908d BindingDB Entry DOI: 10.7270/Q2WH2NRB
Technical University of Dortmund					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
EntreMed Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK2 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
EntreMed Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK3 (Homo sapiens (Human))	BDBM25117 (AG-013736 \| AXITINIB \| N-methyl-2-({3-[(E)-2-(pyri...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
EntreMed Inc. Curated by ChEMBL					More data for this Ligand-Target Pair