Found 19 hits of ic50 for monomerid = 2583 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01467 BindingDB Entry DOI: 10.7270/Q24Q801K |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Bos taurus (bovine)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Laboratoires Glaxo
| Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... |
J Biol Chem 266: 15771-81 (1991)
BindingDB Entry DOI: 10.7270/Q2FF3QJ4 |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 212 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human Protein kinase C beta 2 |
Bioorg Med Chem Lett 14: 5171-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.061 BindingDB Entry DOI: 10.7270/Q2K35VDJ |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 304 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human Protein kinase C beta 1 |
Bioorg Med Chem Lett 14: 5171-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.061 BindingDB Entry DOI: 10.7270/Q2K35VDJ |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Rattus norvegicus (rat)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Roche Products Limited
| Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his... |
J Med Chem 35: 177-84 (1992)
Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V |
More data for this Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase type II subunit delta
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 1.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Scios, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CaMK2delta |
Bioorg Med Chem Lett 18: 2395-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.058 BindingDB Entry DOI: 10.7270/Q2QZ2BVW |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human Protein kinase C alpha |
Bioorg Med Chem Lett 14: 5171-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.061 BindingDB Entry DOI: 10.7270/Q2K35VDJ |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Rattus norvegicus (rat)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
Reactome pathway
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Laboratoires Glaxo
| Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... |
J Biol Chem 266: 15771-81 (1991)
BindingDB Entry DOI: 10.7270/Q2FF3QJ4 |
More data for this Ligand-Target Pair | |
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
(Oryctolagus cuniculus (rabbit)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | UniProtKB/SwissProt
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| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Laboratoires Glaxo
| Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... |
J Biol Chem 266: 15771-81 (1991)
BindingDB Entry DOI: 10.7270/Q2FF3QJ4 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway KEGG
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| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT2 |
J Med Chem 49: 7307-16 (2006)
Article DOI: 10.1021/jm060118b BindingDB Entry DOI: 10.7270/Q2TQ616P |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.81E+3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
DCR&T, Lilly Spain S.A.
| Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP.... |
Bioorg Med Chem Lett 13: 3841-6 (2003)
Article DOI: 10.1016/S0960-894X(03)00792-3 BindingDB Entry DOI: 10.7270/Q2FN14C5 |
More data for this Ligand-Target Pair | |
Protein kinase C epsilon type
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 7.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human Protein kinase C epsilon |
Bioorg Med Chem Lett 14: 5171-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.061 BindingDB Entry DOI: 10.7270/Q2K35VDJ |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
DCR&T, Lilly Spain S.A.
| Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP.... |
Bioorg Med Chem Lett 13: 3841-6 (2003)
Article DOI: 10.1016/S0960-894X(03)00792-3 BindingDB Entry DOI: 10.7270/Q2FN14C5 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Bos taurus (bovine)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
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| Article PubMed
| n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | 8.5 | 37 |
Roche Products Limited
| Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone. |
J Med Chem 35: 177-84 (1992)
Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description Inhibitory concentration was determined by measuring phoshporylation of H1 histone using active human Cell division cycle 2-cyclin B complex |
Bioorg Med Chem Lett 8: 1019-22 (1999)
BindingDB Entry DOI: 10.7270/Q27W6BBN |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Bos taurus (bovine)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
DCR&T, Lilly Spain S.A.
| Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A... |
Bioorg Med Chem Lett 13: 3841-6 (2003)
Article DOI: 10.1016/S0960-894X(03)00792-3 BindingDB Entry DOI: 10.7270/Q2FN14C5 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1/ABL2
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Limited
Curated by ChEMBL
| Assay Description Inhibitory activity against v-abl tyrosine kinase |
J Med Chem 37: 1015-27 (1994)
BindingDB Entry DOI: 10.7270/Q2M32TTP |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Limited
Curated by ChEMBL
| Assay Description Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD) |
J Med Chem 37: 1015-27 (1994)
BindingDB Entry DOI: 10.7270/Q2M32TTP |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase
(Oryctolagus cuniculus (Rabbit)) | BDBM2583
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5| Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) | PDB MMDB
KEGG
UniProtKB/TrEMBL
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| n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Limited
Curated by ChEMBL
| Assay Description Inhibitory activity was determined against protein kinase A (PKA) of rabbit |
J Med Chem 37: 1015-27 (1994)
BindingDB Entry DOI: 10.7270/Q2M32TTP |
More data for this Ligand-Target Pair | |