BindingDB PrimarySearch

Found 50 hits of ic50 for monomerid = 26113
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aspartyl/asparaginyl beta-hydroxylase (Homo sapiens)	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 u...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115675 BindingDB Entry DOI: 10.7270/Q2PV6Q0D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Aspartyl/asparaginyl beta-hydroxylase (Homo sapiens)	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using high 10 uM hFX-CP as substrate mixture with 10 uM 2OG...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115675 BindingDB Entry DOI: 10.7270/Q2PV6Q0D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Aspartyl/asparaginyl beta-hydroxylase (Homo sapiens)	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 u...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115675 BindingDB Entry DOI: 10.7270/Q2PV6Q0D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Aspartyl/asparaginyl beta-hydroxylase (Homo sapiens)	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with high 200 uM 2OG...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115675 BindingDB Entry DOI: 10.7270/Q2PV6Q0D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using biotinylated ...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM5C (unknown origin)				Medchemcomm 5: 1879-1886 (2014) Article DOI: 10.1039/C4MD00291A BindingDB Entry DOI: 10.7270/Q2KH0RBN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Competitive inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using 5...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using ARTKQTARK(Me3...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM5A (1 to 797 residues) (unknown origin) expressed in insect sf21 cells using ARTK(Me3)QTARKSTGGKAPRK peptide/ 100 uM alpha-ketogluta...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using biotinylated ...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A [1-801] (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 4E (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.5	37
University of Oxford					Assay Description A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...				J Med Chem 51: 7053-6 (2008) Article DOI: 10.1021/jm800936s BindingDB Entry DOI: 10.7270/Q2959FV4
University of Oxford					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Competitive inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using 5...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay				J Med Chem 53: 5629-38 (2010) Article DOI: 10.1021/jm1003655 BindingDB Entry DOI: 10.7270/Q2N87B02
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Competitive inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using 2...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5C [1-765] (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis				J Med Chem 56: 547-55 (2013) Article DOI: 10.1021/jm301583m BindingDB Entry DOI: 10.7270/Q26Q1ZJV
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of KDM4C				Bioorg Med Chem Lett 22: 5811-3 (2012) Article DOI: 10.1016/j.bmcl.2012.07.091 BindingDB Entry DOI: 10.7270/Q2222VV7
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4D (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM4D (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K9Me3-GGK-Biotin KDM4 Cognate Ligand/10 uM alpha-ketog...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 5D [1-775] (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM4C (unknown origin)				Medchemcomm 5: 1879-1886 (2014) Article DOI: 10.1039/C4MD00291A BindingDB Entry DOI: 10.7270/Q2KH0RBN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K4Me3-GGK-Biotin KDM5B Cognate Ligand/10 uM alpha-keto...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of recombinant KDM5B catalytic domain (1 to 769 residues) (unknown origin)				Eur J Med Chem 161: 131-140 (2019) Article DOI: 10.1016/j.ejmech.2018.10.040 BindingDB Entry DOI: 10.7270/Q2RB7853
Zhengzhou University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 3A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM3A (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K9Me2-GGK-Biotin KDM3A Cognate Ligand/10 uM alpha-keto...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 2A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM2A (unknown origin)				Medchemcomm 5: 1879-1886 (2014) Article DOI: 10.1039/C4MD00291A BindingDB Entry DOI: 10.7270/Q2KH0RBN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 2A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto Prefectural University of Medicine Curated by ChEMBL					Assay Description Inhibition of KDM2A (unknown origin)				J Med Chem 56: 7222-31 (2013) Article DOI: 10.1021/jm400624b BindingDB Entry DOI: 10.7270/Q2SB475V
Kyoto Prefectural University of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay				J Med Chem 53: 5629-38 (2010) Article DOI: 10.1021/jm1003655 BindingDB Entry DOI: 10.7270/Q2N87B02
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto Prefectural University of Medicine Curated by ChEMBL					Assay Description Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay				J Med Chem 56: 7222-31 (2013) Article DOI: 10.1021/jm400624b BindingDB Entry DOI: 10.7270/Q2SB475V
Kyoto Prefectural University of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl 4-hydroxylase (Paramecium bursaria Chlorella virus 1)	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...				Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 3A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of human recombinant PHD2 expressed in Sf9 cells by time-resolved fluorescence assay				J Med Chem 53: 5629-38 (2010) Article DOI: 10.1021/jm1003655 BindingDB Entry DOI: 10.7270/Q2N87B02
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4E (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM4E (unknown origin)				Medchemcomm 5: 1879-1886 (2014) Article DOI: 10.1039/C4MD00291A BindingDB Entry DOI: 10.7270/Q2KH0RBN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asc...				Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 3A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM3A (unknown origin)				Medchemcomm 5: 1879-1886 (2014) Article DOI: 10.1039/C4MD00291A BindingDB Entry DOI: 10.7270/Q2KH0RBN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto Prefectural University of Medicine Curated by ChEMBL					Assay Description Inhibition of KDM4C (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay				J Med Chem 56: 7222-31 (2013) Article DOI: 10.1021/jm400624b BindingDB Entry DOI: 10.7270/Q2SB475V
Kyoto Prefectural University of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-ketoglutarate-dependent dioxygenase FTO (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...				J Med Chem 56: 3680-8 (2013) Article DOI: 10.1021/jm400193d BindingDB Entry DOI: 10.7270/Q21V5GBQ
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hypoxia-inducible factor 1-alpha inhibitor (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged full-length FIH (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using SMDESGLPQLTSYDCEVNAPIQG...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay				J Med Chem 53: 5629-38 (2010) Article DOI: 10.1021/jm1003655 BindingDB Entry DOI: 10.7270/Q2N87B02
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 2A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 2A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.28E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM2A (unknown origin) expressed in Escherichia coli using Biotin H3 (28 to 48 residues) Me2 KDM2A Cognate Ligande/10 uM alpha-ketoglut...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM6B (unknown origin)				Medchemcomm 5: 1879-1886 (2014) Article DOI: 10.1039/C4MD00291A BindingDB Entry DOI: 10.7270/Q2KH0RBN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK after 30 mins by FDH-coupled assay				Bioorg Med Chem Lett 22: 5811-3 (2012) Article DOI: 10.1016/j.bmcl.2012.07.091 BindingDB Entry DOI: 10.7270/Q2222VV7
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	7.5	n/a
University of Oxford					Assay Description The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...				Nat Chem Biol 12: 539-45 (2016) Article DOI: 10.1038/nchembio.2087 BindingDB Entry DOI: 10.7270/Q27P8X6K
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of KDM6B (unknown origin) expressed in Escherichia coli using H3 (21 to 44 residues) K27Me3-GGK-Biotin JMJD3 Cognate Ligand/10 uM alpha-ke...				J Med Chem 59: 1580-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-editing ligase 1, mitochondrial (Trypanosoma brucei brucei)	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PCBioAssay	n/a	n/a	>9.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2P26WT9
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto Prefectural University of Medicine Curated by ChEMBL					Assay Description Inhibition of KDM5A (unknown origin) using H3K4me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay				J Med Chem 56: 7222-31 (2013) Article DOI: 10.1021/jm400624b BindingDB Entry DOI: 10.7270/Q2SB475V
Kyoto Prefectural University of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 6A (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.77E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of KDM6A				Bioorg Med Chem Lett 22: 5811-3 (2012) Article DOI: 10.1016/j.bmcl.2012.07.091 BindingDB Entry DOI: 10.7270/Q2222VV7
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM26113 (2,4 PDCA \| cid_10365 \| pyridine carboxylate, 6a \| ...) Show SMILES OC(=O)c1ccnc(c1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	6.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of PHD1 by HTRF assay				Bioorg Med Chem Lett 20: 6125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.08.032 BindingDB Entry DOI: 10.7270/Q22B8Z7F
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair