Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 9.0 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.... | US Patent US9169224 (2015) BindingDB Entry DOI: 10.7270/Q24Q7ST1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 9.0 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.... | US Patent US9169224 (2015) BindingDB Entry DOI: 10.7270/Q24Q7ST1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis (R&D) Ltd Curated by ChEMBL | Assay Description Inhibition of FAAH | Bioorg Med Chem Lett 19: 4241-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.097 BindingDB Entry DOI: 10.7270/Q28S4PZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21 preincubated for 60 mins followe... | J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 350 | n/a | n/a | n/a | n/a | 9.0 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris... | US Patent US9169224 (2015) BindingDB Entry DOI: 10.7270/Q24Q7ST1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 473 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universit£ di Roma Curated by ChEMBL | Assay Description Inhibition of FAAH-mediated hydrolysis of [3H]AEA in rat brain membrane | Bioorg Med Chem Lett 19: 6806-9 (2009) Article DOI: 10.1016/j.bmcl.2009.09.033 BindingDB Entry DOI: 10.7270/Q2P55NNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 687 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 991 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21-AI preincubated for 5 mins follo... | J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 991 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o... | Biochemistry 46: 13019-30 (2007) Article DOI: 10.1021/bi701378g BindingDB Entry DOI: 10.7270/Q2VT1QCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM26741 (N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universit£ di Roma Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as decrease in intracellular calcium level | Bioorg Med Chem Lett 19: 6806-9 (2009) Article DOI: 10.1016/j.bmcl.2009.09.033 BindingDB Entry DOI: 10.7270/Q2P55NNT | |||||||||||
More data for this Ligand-Target Pair |