Found 37 hits of ic50 for monomerid = 32362 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chung-Ang University
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human N-terminal His6-tagged FMS (538 to end residues) expressed in baculovirus infected Sf21 insect cells using I... |
Bioorg Med Chem Lett 29: 271-275 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.037 BindingDB Entry DOI: 10.7270/Q2QJ7MN8 |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal GST-tagged CSF1R (unknown origin) (547 to 980 residues) expressed in baculovirus infected Sf9 cells using biotin-EAIYAPFAKKK... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113298 BindingDB Entry DOI: 10.7270/Q2GX4GB2 |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CFMS kinase catalytic domain using biotin-EAIYAPFAKKK-NH2 as substrate after 40 mins by NXT scintillation ... |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CSF1R (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00936 BindingDB Entry DOI: 10.7270/Q2Q81HSS |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of cFMS |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences
Curated by ChEMBL
| Assay Description Inhibition of human CSF1R catalytic domain by ATP-based kinase assay |
J Med Chem 62: 1731-1760 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01092 BindingDB Entry DOI: 10.7270/Q29Z986G |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sharjah
Curated by ChEMBL
| Assay Description Inhibition of CSF1R (unknown origin) |
J Med Chem 61: 5450-5466 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00873 BindingDB Entry DOI: 10.7270/Q2P55R5S |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sharjah
Curated by ChEMBL
| Assay Description Inhibition of CSF1R in human monocytes assessed as inhibition of IL34-stimulated MCP release |
J Med Chem 61: 5450-5466 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00873 BindingDB Entry DOI: 10.7270/Q2P55R5S |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sharjah
Curated by ChEMBL
| Assay Description Inhibition of CSF1R in human monocytes assessed as inhibition of CSF1-stimulated MCP release |
J Med Chem 61: 5450-5466 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00873 BindingDB Entry DOI: 10.7270/Q2P55R5S |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Mus musculus (Mouse)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
KEGG
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| n/a | n/a | 392 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CSF1R in mouse MNFS-60 cells assessed as reduction in CSF-induced cell viability after 48 hrs by Ez-cytox reagent based assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113298 BindingDB Entry DOI: 10.7270/Q2GX4GB2 |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01571 BindingDB Entry DOI: 10.7270/Q25H7MBX |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
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| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01571 BindingDB Entry DOI: 10.7270/Q25H7MBX |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
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| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences
Curated by ChEMBL
| Assay Description Inhibition of TRKA (unknown origin) by ATP site-dependent competition binding assay |
J Med Chem 62: 1731-1760 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01092 BindingDB Entry DOI: 10.7270/Q29Z986G |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | >4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His-tagged B-RAF after 60 mins by fluorescence polarization assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged ERK2 after 60 mins by fluorescence polarization assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human PDGFR-1b |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged MK2 using K(biotin)KLNRTLSVA as substrate after 2 hrs by scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of mouse LCK |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
Reactome pathway KEGG
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| n/a | n/a | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human JAK2 catalytic domain after by scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human FLT3 catalytic domain after by scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human PKCb1 catalytic domain after by scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human PKCa catalytic domain after by scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
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| n/a | n/a | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human cKIT catalytic domain after by scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human SYK |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human JNK3 |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ITK/TSK
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human ITK |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human GST-tagged c-SRC autophosphorylation using biotin-(6-amino caproic acid)-AAAQQIYGQ-NH2 as substrate after 40 mins by homogenous t... |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | >1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CDK4 catalytic domain after 30 mins by liquid scintillation counting |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human GST-tagged VEGFR2 catalytic domain using biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate after 40 mins by homogenous time-resol... |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human GST-tagged Tie2 using biotin-(6-amino caproic acid)-LEARLVAYEGWVAGKKK-NH2 after 2 hrs by homogenous time-resolved fluorescence me... |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Patents
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| n/a | n/a | >2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged PKCz using biotin-(amino hexanoic acid)-FKLKRKGSFKKFA-CONH2 as substrate after 40 mins by scintillation proximity assa... |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| n/a | n/a | >2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged EGFR using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | >2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged ERBB2 using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | >2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human GST-tagged PLK1 using biotin-amino hexanoic acid-SFNDTLDFD-NH2 as substrate after 15 mins by scintillation proximity assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-4
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | >2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged ERBB4 using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
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| n/a | n/a | >2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged PDHK4 using biotin-YHGHSMSDPGVSYRRR-amide as substrate after 20 mins by scintillation proximity assay |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM32362
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged GSK-3b using biotin-6-amino caproic acid-AAAKRREILSRRPS(PO3)YR-amide as substrate after 19 mins by NXT scintillation c... |
Proc Natl Acad Sci U S A 102: 16078-83 (2005)
Article DOI: 10.1073/pnas.0502000102 BindingDB Entry DOI: 10.7270/Q2PC32TB |
More data for this Ligand-Target Pair | |