Compile Data Set for Download or QSAR

Found 10 hits of ic50 for monomerid = 339837   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.07	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.45	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.48	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.74	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.86	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.86	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.29	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.94	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM339837 (US9757364, Compound 40 | US9757364, Compound 43) Show SMILES COc1cc(OC)c(F)c(c1)N(CC1CCC(=O)N1)c1ccc2ncc(cc2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H25FN6O3/c1-31-13-16(12-28-31)15-8-20-19(27-11-15)5-6-23(30-20)32(14-17-4-7-24(33)29-17)21-9-18(34-2)10-22(35-3)25(21)26/h5-6,8-13,17H,4,7,14H2,1-3H3,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.4	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair