Found 8 hits of ic50 for monomerid = 342472 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Celon Pharma S.A.
US Patent
| Assay Description
The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E... |
US Patent US9776988 (2017)
BindingDB Entry DOI: 10.7270/Q27946S6 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112990
BindingDB Entry DOI: 10.7270/Q2WD44HQ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112990
BindingDB Entry DOI: 10.7270/Q2WD44HQ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celon Pharma S.A.
US Patent
| Assay Description
The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E... |
US Patent US9776988 (2017)
BindingDB Entry DOI: 10.7270/Q27946S6 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 29.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Celon Pharma S.A.
US Patent
| Assay Description
The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E... |
US Patent US9776988 (2017)
BindingDB Entry DOI: 10.7270/Q27946S6 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112990
BindingDB Entry DOI: 10.7270/Q2WD44HQ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 82.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Celon Pharma S.A.
US Patent
| Assay Description
The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E... |
US Patent US9776988 (2017)
BindingDB Entry DOI: 10.7270/Q27946S6 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM342472
(US9776988, Example 4)Show SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)C(=O)NCCN2CCOCC2)cc(OC)c1 Show InChI InChI=1S/C27H32N6O4/c1-35-21-13-18(14-22(17-21)36-2)3-5-20-16-25(32-31-20)26-29-23-6-4-19(15-24(23)30-26)27(34)28-7-8-33-9-11-37-12-10-33/h4,6,13-17H,3,5,7-12H2,1-2H3,(H,28,34)(H,29,30)(H,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112990
BindingDB Entry DOI: 10.7270/Q2WD44HQ |
More data for this
Ligand-Target Pair | |
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