Found 8 hits of ic50 for monomerid = 346178 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Rattus norvegicus (Rat)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Rattus norvegicus (Rat)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM346178
(US10202371, Example 8)Show SMILES CCC1C(OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C23H23F3N8O3/c1-2-16-18(13-4-3-5-28-11-13)37-22(35)34(16)17-10-15(30-21(31-17)33-6-8-36-9-7-33)14-12-29-20(27)32-19(14)23(24,25)26/h3-5,10-12,16,18H,2,6-9H2,1H3,(H2,27,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |