Found 8 hits of ic50 for monomerid = 346186 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 236 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Rattus norvegicus (Rat)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 606 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Rattus norvegicus (Rat)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM346186
(WO2007/084786, Compound 18)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCN(C2=O)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8O2/c23-22(24,25)18-15(13-27-19(26)30-18)16-12-17(29-20(28-16)31-8-10-35-11-9-31)33-7-6-32(21(33)34)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |