Found 4 hits of ic50 for monomerid = 35577 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35577
(pyrazolo pyrimidine, 12)Show SMILES OCCOC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1 Show InChI InChI=1S/C29H34N8O4/c38-14-17-41-29(39)32-23-5-3-22(4-6-23)26-33-27(36-12-15-40-16-13-36)25-19-31-37(28(25)34-26)24-7-10-35(11-8-24)20-21-2-1-9-30-18-21/h1-6,9,18-19,24,38H,7-8,10-17,20H2,(H,32,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 5013-6 (2009)
Article DOI: 10.1021/jm900851f
BindingDB Entry DOI: 10.7270/Q2SJ1HZD |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35577
(pyrazolo pyrimidine, 12)Show SMILES OCCOC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1 Show InChI InChI=1S/C29H34N8O4/c38-14-17-41-29(39)32-23-5-3-22(4-6-23)26-33-27(36-12-15-40-16-13-36)25-19-31-37(28(25)34-26)24-7-10-35(11-8-24)20-21-2-1-9-30-18-21/h1-6,9,18-19,24,38H,7-8,10-17,20H2,(H,32,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells |
J Med Chem 52: 8010-24 (2009)
Article DOI: 10.1021/jm9013828
BindingDB Entry DOI: 10.7270/Q28W3DGF |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35577
(pyrazolo pyrimidine, 12)Show SMILES OCCOC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1 Show InChI InChI=1S/C29H34N8O4/c38-14-17-41-29(39)32-23-5-3-22(4-6-23)26-33-27(36-12-15-40-16-13-36)25-19-31-37(28(25)34-26)24-7-10-35(11-8-24)20-21-2-1-9-30-18-21/h1-6,9,18-19,24,38H,7-8,10-17,20H2,(H,32,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha by DELFIA assay |
J Med Chem 52: 8010-24 (2009)
Article DOI: 10.1021/jm9013828
BindingDB Entry DOI: 10.7270/Q28W3DGF |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35577
(pyrazolo pyrimidine, 12)Show SMILES OCCOC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1 Show InChI InChI=1S/C29H34N8O4/c38-14-17-41-29(39)32-23-5-3-22(4-6-23)26-33-27(36-12-15-40-16-13-36)25-19-31-37(28(25)34-26)24-7-10-35(11-8-24)20-21-2-1-9-30-18-21/h1-6,9,18-19,24,38H,7-8,10-17,20H2,(H,32,39) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 5013-6 (2009)
Article DOI: 10.1021/jm900851f
BindingDB Entry DOI: 10.7270/Q2SJ1HZD |
More data for this
Ligand-Target Pair | |
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