Found 14 hits of ic50 for monomerid = 4363 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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| Article PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universität Berlin
Curated by ChEMBL
| Assay Description Inhibition of human EGFR tyrosine kinase activity |
Eur J Med Chem 43: 1478-88 (2008)
Article DOI: 10.1016/j.ejmech.2007.09.018 BindingDB Entry DOI: 10.7270/Q2D50MRC |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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| Article PubMed
| 850 | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hebrew University of Jerusalem
| Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. |
J Med Chem 32: 2344-52 (1989)
Article DOI: 10.1021/jm00130a020 BindingDB Entry DOI: 10.7270/Q2G44NHF |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Molecular Physiology
Curated by ChEMBL
| Assay Description Inhibition of EGFR |
Bioorg Med Chem 17: 1079-87 (2009)
Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4 |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
() | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB
UniProtKB/SwissProt
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| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... |
J Biol Chem 282: 4085-93 (2007)
Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N |
More data for this Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2/Receptor protein-tyrosine kinase
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Duke University Medical Center
| Assay Description In order to eliminated fluorescence interference, chemicals were subjected to a secondary screening using colorimetric BP incorporation assay. TGase... |
Chem Biol 15: 969-78 (2008)
Article DOI: 10.1016/j.chembiol.2008.07.015 BindingDB Entry DOI: 10.7270/Q2DR2SZR |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-678,753-922]
(Human Sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB
UniProtKB/SwissProt
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... |
J Biol Chem 282: 4085-93 (2007)
Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of EGFR in human A431 cells |
J Nat Prod 55: 1529-1560 (1992)
Article DOI: 10.1021/np50089a001 BindingDB Entry DOI: 10.7270/Q2J966CC |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-678,753-922]
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... |
J Biol Chem 282: 4085-93 (2007)
Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universität Berlin
Curated by ChEMBL
| Assay Description Inhibition of human HER2 tyrosine kinase activity |
Eur J Med Chem 43: 1478-88 (2008)
Article DOI: 10.1016/j.ejmech.2007.09.018 BindingDB Entry DOI: 10.7270/Q2D50MRC |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of EGF-dependent proliferation of human and guinea pig keratinocytes; range 7-15 uM |
J Med Chem 44: 281-97 (2001)
BindingDB Entry DOI: 10.7270/Q2NP2541 |
More data for this Ligand-Target Pair | |
Tyrosyl-DNA phosphodiesterase 1
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'... |
J Med Chem 55: 8671-84 (2012)
Article DOI: 10.1021/jm3008773 BindingDB Entry DOI: 10.7270/Q2MP54D1 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant Syk (unknown origin) |
Bioorg Med Chem Lett 19: 1944-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98 |
More data for this Ligand-Target Pair | |
Dynamin-1
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Newcastle
Curated by ChEMBL
| Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain |
J Med Chem 48: 7781-8 (2005)
Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41 |
More data for this Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM4363
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | PDB MMDB
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CHEMBL MCE PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 6.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Molecular Physiology
Curated by ChEMBL
| Assay Description Inhibition of IRK |
Bioorg Med Chem 17: 1079-87 (2009)
Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4 |
More data for this Ligand-Target Pair | |