BindingDB PrimarySearch

Found 8 hits of ic50 for monomerid = 50007260
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine protease hepsin (Homo sapiens (Human))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	US Patent	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Fred Hutchinson Cancer Research Center US Patent					Assay Description To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...				US Patent US9182402 (2015) BindingDB Entry DOI: 10.7270/Q23F4NF7
Fred Hutchinson Cancer Research Center US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SIRT5 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112676 BindingDB Entry DOI: 10.7270/Q2X3526F
TBA					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
AtheroGenics, Inc. Curated by ChEMBL					Assay Description Inhibition of 15-lipoxygenase by LMB assay				J Med Chem 47: 6420-32 (2004) Article DOI: 10.1021/jm049685u BindingDB Entry DOI: 10.7270/Q2RB75D0
AtheroGenics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Bos taurus (Bovine))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Fred Hutchinson Cancer Research Center US Patent					Assay Description To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...				US Patent US9182402 (2015) BindingDB Entry DOI: 10.7270/Q23F4NF7
Fred Hutchinson Cancer Research Center US Patent					More data for this Ligand-Target Pair
Trypsin (Sus scrofa)	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	US Patent	n/a	n/a	3.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
Fred Hutchinson Cancer Research Center US Patent					Assay Description To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...				US Patent US9182402 (2015) BindingDB Entry DOI: 10.7270/Q23F4NF7
Fred Hutchinson Cancer Research Center US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2J2 (Homo sapiens (Human))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tongji University Curated by ChEMBL					Assay Description Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method				Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G
Tongji University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular cell adhesion protein 1 (Homo sapiens (Human))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AtheroGenics, Inc. Curated by ChEMBL					Assay Description Inhibition of TNF-alpha inducible Vascular cell adhesion molecule-1 expression.				Bioorg Med Chem Lett 12: 2545-8 (2002) BindingDB Entry DOI: 10.7270/Q23X860C
AtheroGenics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50007260 (2,6-Di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydrox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair