Found 7 hits of ic50 for monomerid = 50020584 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas... |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi... |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me... |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a... |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysis |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid lipoxygenase ALOX12
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of 12-LO in human neutrophils |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50020584
(CHEMBL2413471)Show SMILES COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University Jena
Curated by ChEMBL
| Assay Description
Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay |
J Med Chem 57: 5638-48 (2014)
Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN |
More data for this
Ligand-Target Pair | |
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