Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50073056 (4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense de Madrid Curated by ChEMBL | Assay Description Inhibition of human recombinant 5HT6 receptor expressed in CHO cells | J Med Chem 57: 7160-81 (2014) Article DOI: 10.1021/jm5003952 BindingDB Entry DOI: 10.7270/Q2X92CZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50073056 (4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human cytochrome P450 3A4 as total cyclosporin oxidation (1 uM) | J Med Chem 42: 202-5 (1999) Article DOI: 10.1021/jm980532e BindingDB Entry DOI: 10.7270/Q2PC31KS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50073056 (4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human cytochrome P450 1A2 activity as caffeine N3 demethylation (500 uM) | J Med Chem 42: 202-5 (1999) Article DOI: 10.1021/jm980532e BindingDB Entry DOI: 10.7270/Q2PC31KS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50073056 (4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human cytochrome P450 2D6 as bufuralol 1''-hydroxylation (10 uM) | J Med Chem 42: 202-5 (1999) Article DOI: 10.1021/jm980532e BindingDB Entry DOI: 10.7270/Q2PC31KS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50073056 (4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human cytochrome P450 2C19 as S-mephenytoin-4-hydroxylation (100 uM) | J Med Chem 42: 202-5 (1999) Article DOI: 10.1021/jm980532e BindingDB Entry DOI: 10.7270/Q2PC31KS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50073056 (4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory potential of human cytochrome P450 2C9 as tolbutamide methylhydroxylation (100 uM) | J Med Chem 42: 202-5 (1999) Article DOI: 10.1021/jm980532e BindingDB Entry DOI: 10.7270/Q2PC31KS | |||||||||||
More data for this Ligand-Target Pair |