Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Inhibition of hypoxia-induced HIF1 activation in human HeLa cells by luciferase reporter gene assay | J Nat Prod 68: 947-50 (2005) Article DOI: 10.1021/np050029m BindingDB Entry DOI: 10.7270/Q23J3GRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
COUP transcription factor 2 (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q21Z431S | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Compound was evaluated for its inhibitory effect on human FK506 binding protein 12 by means of protease-coupled PPIase assay | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tegument protein VP16 (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 8.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q2GM85ZT | |||||||||||
More data for this Ligand-Target Pair |