Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham Curated by ChEMBL | Assay Description Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio... | J Med Chem 62: 6214-6222 (2019) Article DOI: 10.1021/acs.jmedchem.9b00519 BindingDB Entry DOI: 10.7270/Q2F47SGG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Antagonist activity at GluR1 expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current at -60mV holding potential by tw... | J Med Chem 53: 7441-51 (2010) Article DOI: 10.1021/jm100886h BindingDB Entry DOI: 10.7270/Q2125SX4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham Curated by ChEMBL | Assay Description Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio... | J Med Chem 62: 6214-6222 (2019) Article DOI: 10.1021/acs.jmedchem.9b00519 BindingDB Entry DOI: 10.7270/Q2F47SGG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1/2A (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ... | J Med Chem 53: 7441-51 (2010) Article DOI: 10.1021/jm100886h BindingDB Entry DOI: 10.7270/Q2125SX4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Rattus norvegicus (Rat)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/beta/delta/gamma (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value). | J Med Chem 43: 4526-33 (2000) Article DOI: 10.1021/jm000220n BindingDB Entry DOI: 10.7270/Q2F192F2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/beta/delta/gamma (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (peak value). | J Med Chem 43: 4526-33 (2000) Article DOI: 10.1021/jm000220n BindingDB Entry DOI: 10.7270/Q2F192F2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit delta (Homo sapiens (Human)) | BDBM50094298 (CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres... | Bioorg Med Chem Lett 12: 1159-62 (2002) BindingDB Entry DOI: 10.7270/Q2BC3XWG | |||||||||||
More data for this Ligand-Target Pair |