BindingDB PrimarySearch

Found 16 hits of ic50 for monomerid = 50097346
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
ZAFES/LiFF/Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of human recombinant COX2 after 5 mins				J Med Chem 53: 4691-700 (2010) Article DOI: 10.1021/jm1003073 BindingDB Entry DOI: 10.7270/Q2N016PB
ZAFES/LiFF/Goethe University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against cell-free canine COX-2				J Med Chem 44: 641-59 (2001) BindingDB Entry DOI: 10.7270/Q2J965NJ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis				Bioorg Med Chem 19: 5372-82 (2011) Article DOI: 10.1016/j.bmc.2011.08.003 BindingDB Entry DOI: 10.7270/Q2JQ11D0
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay				J Med Chem 55: 8807-26 (2012) Article DOI: 10.1021/jm3011146 BindingDB Entry DOI: 10.7270/Q2G161ZJ
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
ZAFES/LiFF/Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of ovine COX1 after 5 mins				J Med Chem 53: 4691-700 (2010) Article DOI: 10.1021/jm1003073 BindingDB Entry DOI: 10.7270/Q2N016PB
ZAFES/LiFF/Goethe University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against cell-free canine COX-1				J Med Chem 44: 641-59 (2001) BindingDB Entry DOI: 10.7270/Q2J965NJ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis				Bioorg Med Chem 19: 5372-82 (2011) Article DOI: 10.1016/j.bmc.2011.08.003 BindingDB Entry DOI: 10.7270/Q2JQ11D0
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay				J Med Chem 55: 8807-26 (2012) Article DOI: 10.1021/jm3011146 BindingDB Entry DOI: 10.7270/Q2G161ZJ
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Cagliari Curated by ChEMBL					Assay Description Inhibition of rat brain FAAH using [3H]AEA as substrate				Eur J Med Chem 136: 523-542 (2017) Article DOI: 10.1016/j.ejmech.2017.05.033 BindingDB Entry DOI: 10.7270/Q2H134JK
University of Cagliari Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Lille 2 Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood				Bioorg Med Chem Lett 18: 4655-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.018 BindingDB Entry DOI: 10.7270/Q2G73DH6
Université de Lille 2 Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Lille 2 Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood				Bioorg Med Chem Lett 18: 4655-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.018 BindingDB Entry DOI: 10.7270/Q2G73DH6
Université de Lille 2 Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	7.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid ...				J Med Chem 55: 8807-26 (2012) Article DOI: 10.1021/jm3011146 BindingDB Entry DOI: 10.7270/Q2G161ZJ
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
ATP-binding cassette sub-family C member 3 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50097346 ((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...) Show SMILES CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair