Found 11 hits of ic50 for monomerid = 50105066 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand |
J Med Chem 44: 3378-90 (2001)
BindingDB Entry DOI: 10.7270/Q23X87B8 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against mu opiate receptor |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand |
J Med Chem 44: 3378-90 (2001)
BindingDB Entry DOI: 10.7270/Q23X87B8 |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligand |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand |
J Med Chem 44: 3378-90 (2001)
BindingDB Entry DOI: 10.7270/Q23X87B8 |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Inhibition of ligand binding to human delta opioid receptor. |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Inhibition of human ORL1 orphanin receptor |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 556 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against M1 muscarinic receptor |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 663 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Inhibition of human 5-hydroxytryptamine 7 receptor |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Binding affinity against L-type calcium channel verapamil site |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50105066
(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)Show SMILES Cc1ccc2[nH]c(=O)n(C3CCN(Cc4cc5OCOc5cc4Cl)CC3)c2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-2-3-17-18(8-13)25(21(26)23-17)15-4-6-24(7-5-15)11-14-9-19-20(10-16(14)22)28-12-27-19/h2-3,8-10,15H,4-7,11-12H2,1H3,(H,23,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille
Curated by ChEMBL
| Assay Description
Inhibition of alpha-1 adrenergic receptor |
J Med Chem 44: 3391-401 (2001)
BindingDB Entry DOI: 10.7270/Q2057GN9 |
More data for this
Ligand-Target Pair | |
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