Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thiosulfate sulfurtransferase (Homo sapiens) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ... | Bioorg Med Chem Lett 29: 1106-1112 (2019) Article DOI: 10.1016/j.bmcl.2019.02.028 BindingDB Entry DOI: 10.7270/Q2NZ8C33 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri Curated by ChEMBL | Assay Description Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay | Bioorg Med Chem Lett 22: 4844-8 (2012) Article DOI: 10.1016/j.bmcl.2012.05.041 BindingDB Entry DOI: 10.7270/Q2SJ1PG6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA | Eur J Med Chem 90: 889-96 (2015) Article DOI: 10.1016/j.ejmech.2014.12.013 BindingDB Entry DOI: 10.7270/Q29S1SP6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA | Eur J Med Chem 74: 717-25 (2014) Article DOI: 10.1016/j.ejmech.2013.06.014 BindingDB Entry DOI: 10.7270/Q21G0NRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 2.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology Curated by ChEMBL | Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method | Bioorg Med Chem Lett 26: 1508-11 (2016) Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Guizhou University Curated by ChEMBL | Assay Description Inhibition of telomerase in human MDA-MB-231 cells after 24 hrs by TRAP-PCR-ELISA | Eur J Med Chem 97: 155-63 (2015) Article DOI: 10.1016/j.ejmech.2015.04.063 BindingDB Entry DOI: 10.7270/Q2PZ5BH7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Guizhou University Curated by ChEMBL | Assay Description Inhibition of telomerase-mediated supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay | Bioorg Med Chem Lett 23: 720-3 (2013) Article DOI: 10.1016/j.bmcl.2012.11.101 BindingDB Entry DOI: 10.7270/Q2HD7X07 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Co-chaperonin GroES (Escherichia coli) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ... | Bioorg Med Chem Lett 29: 1106-1112 (2019) Article DOI: 10.1016/j.bmcl.2019.02.028 BindingDB Entry DOI: 10.7270/Q2NZ8C33 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of telomerase supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay | Eur J Med Chem 51: 294-9 (2012) Article DOI: 10.1016/j.ejmech.2012.02.040 BindingDB Entry DOI: 10.7270/Q28053M9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui University of Technology Curated by ChEMBL | Assay Description Inhibition of telomerase in human SGC7901 cells by TRAP assay | Bioorg Med Chem Lett 20: 5705-8 (2010) Article DOI: 10.1016/j.bmcl.2010.08.017 BindingDB Entry DOI: 10.7270/Q2P84C30 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of telomerase in human SGC7901 cells by TRAP assay | Bioorg Med Chem 18: 7836-41 (2010) Article DOI: 10.1016/j.bmc.2010.09.051 BindingDB Entry DOI: 10.7270/Q2930TDR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of telomerase activity expressed in human SGC7901 cells by SYBER green dye based TRAP | Bioorg Med Chem Lett 21: 2916-20 (2011) Article DOI: 10.1016/j.bmcl.2011.03.066 BindingDB Entry DOI: 10.7270/Q2N016VK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of telomerase in human SGC7901 cells by TRAP assay | Bioorg Med Chem Lett 23: 1091-5 (2013) Article DOI: 10.1016/j.bmcl.2012.12.010 BindingDB Entry DOI: 10.7270/Q2668FJ4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri Curated by ChEMBL | Assay Description Inhibitory activity of the compound against telomerase (Compound released from RNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3) | Bioorg Med Chem Lett 11: 2727-30 (2001) BindingDB Entry DOI: 10.7270/Q2PN94XJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri Curated by ChEMBL | Assay Description Inhibitory activity of the compound against telomerase (Compound released from underivatized resin | Bioorg Med Chem Lett 11: 2727-30 (2001) BindingDB Entry DOI: 10.7270/Q2PN94XJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri Curated by ChEMBL | Assay Description Inhibitory activity of the compound against telomerase (Compound released from DNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3) | Bioorg Med Chem Lett 11: 2727-30 (2001) BindingDB Entry DOI: 10.7270/Q2PN94XJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Co-chaperonin GroES (Escherichia coli) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a... | Bioorg Med Chem Lett 29: 1106-1112 (2019) Article DOI: 10.1016/j.bmcl.2019.02.028 BindingDB Entry DOI: 10.7270/Q2NZ8C33 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 60 kDa heat shock protein, mitochondrial (Homo sapiens) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset... | Bioorg Med Chem Lett 29: 1106-1112 (2019) Article DOI: 10.1016/j.bmcl.2019.02.028 BindingDB Entry DOI: 10.7270/Q2NZ8C33 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Chaperonin GroEL (Escherichia coli) | BDBM50105463 (2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys... | Bioorg Med Chem Lett 29: 1106-1112 (2019) Article DOI: 10.1016/j.bmcl.2019.02.028 BindingDB Entry DOI: 10.7270/Q2NZ8C33 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
