Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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M-phase inducer phosphatase 2 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human cell division cycle 25B | J Med Chem 44: 4042-9 (2001) BindingDB Entry DOI: 10.7270/Q2X34WR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-lysine methyltransferase KMT5A (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
The Center for Combinatorial Chemistry and Drug Discovery of Jilin University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst... | Bioorg Med Chem Lett 26: 4436-4440 (2016) Article DOI: 10.1016/j.bmcl.2016.08.004 BindingDB Entry DOI: 10.7270/Q27H1P3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-lysine methyltransferase KMT5A (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p... | J Med Chem 58: 1596-629 (2015) Article DOI: 10.1021/jm501234a BindingDB Entry DOI: 10.7270/Q28K7BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
M-phase inducer phosphatase 3 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour Curated by ChEMBL | Assay Description Inhibitory activity against recombinant CDC25C | Bioorg Med Chem Lett 16: 171-5 (2005) Article DOI: 10.1016/j.bmcl.2005.09.030 BindingDB Entry DOI: 10.7270/Q2T1535S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
M-phase inducer phosphatase 3 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of recombinant human Cdc25C using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111696 BindingDB Entry DOI: 10.7270/Q21R6TS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
M-phase inducer phosphatase 1 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of recombinant human Cdc25A using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111696 BindingDB Entry DOI: 10.7270/Q21R6TS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
M-phase inducer phosphatase 2 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of recombinant human Cdc25B using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111696 BindingDB Entry DOI: 10.7270/Q21R6TS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein phosphatase 3 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibitory Activity against Recombinant Human VHR | J Med Chem 44: 4042-9 (2001) BindingDB Entry DOI: 10.7270/Q2X34WR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human)) | BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibitory Activity against Recombinant Human PTP1 | J Med Chem 44: 4042-9 (2001) BindingDB Entry DOI: 10.7270/Q2X34WR5 | |||||||||||
More data for this Ligand-Target Pair |