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Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
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Compile Data Set for Download or QSAR
Found
3
hits of ic50 for monomerid = 50138134
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human))
BDBM50138134
(CHEMBL3754611)
Show SMILES
NC(=O)c1ccc(cc1)-n1cc(cn1)-c1ccc(Cl)cc1
Show InChI
InChI=1S/C16H12ClN3O/c17-14-5-1-11(2-6-14)13-9-19-20(10-13)15-7-3-12(4-8-15)16(18)21/h1-10H,(H2,18,21)
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
248
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assay
ACS Med Chem Lett
6:
1128
-
33
(2015)
Article DOI:
10.1021/acsmedchemlett.5b00215
BindingDB Entry DOI:
10.7270/Q2028TC6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human))
BDBM50138134
(CHEMBL3754611)
Show SMILES
NC(=O)c1ccc(cc1)-n1cc(cn1)-c1ccc(Cl)cc1
Show InChI
InChI=1S/C16H12ClN3O/c17-14-5-1-11(2-6-14)13-9-19-20(10-13)15-7-3-12(4-8-15)16(18)21/h1-10H,(H2,18,21)
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of recombinant human MAP4K4 catalytic domain in presence of 1 mM ATP by FRET assay
ACS Med Chem Lett
6:
1128
-
33
(2015)
Article DOI:
10.1021/acsmedchemlett.5b00215
BindingDB Entry DOI:
10.7270/Q2028TC6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human))
BDBM50138134
(CHEMBL3754611)
Show SMILES
NC(=O)c1ccc(cc1)-n1cc(cn1)-c1ccc(Cl)cc1
Show InChI
InChI=1S/C16H12ClN3O/c17-14-5-1-11(2-6-14)13-9-19-20(10-13)15-7-3-12(4-8-15)16(18)21/h1-10H,(H2,18,21)
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISA
ACS Med Chem Lett
6:
1128
-
33
(2015)
Article DOI:
10.1021/acsmedchemlett.5b00215
BindingDB Entry DOI:
10.7270/Q2028TC6
More data for this
Ligand-Target Pair
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